Fungicidal compositions

ABSTRACT

A composition suitable for control of diseases caused by phytopathogens comprising a mixture of a compound of formula I 
                         
with two compounds selected from compounds known for their fungicidal activity; and a method of controlling diseases on useful plants.

RELATED APPLICATION INFORMATION

This application is a continuation of U.S. patent application Ser. No. 14/416,775 filed on 23 Jan. 2015 which is a 371 of International Application No. PCT/EP2013/065480, filed 23 Jul. 2013, which claims priority to 12177995.3, filed 26 Jul. 2012, the contents of which are incorporated by reference herein.

The present invention relates to novel fungicidal compositions for the treatment of phytopathogenic diseases of useful plants, especially phytopathogenic fungi, and to a method of controlling phytopathogenic diseases on useful plants.

It is known from WO2008/148570, WO 2010/063700, WO 2010/084078 and WO 2008/151828 that certain pyrazolyl-carboxamide derivatives have biological activity against phytopathogenic fungi. On the other hand various fungicidal compounds of different chemical classes are widely known as plant fungicides for application in various crops of cultivated plants. However, crop tolerance and activity against phytopathogenic plant fungi do not always satisfy the needs of agricultural practice in many incidents and aspects. In order to overcome this problem, binary mixtures of pyrazolyl-carboxamides with certain fungicides have been provided in WO 2012/041874.

It has now been found that the addition of a specific further fungicide to compositions comprising the binary mixtures disclosed in WO 2012/041874 leads to novel ternary fungicidal compositions with advantageous properties.

There is therefore proposed in accordance with the invention a novel composition suitable for the control of diseases caused by phytopathogens comprising

as component (A) a compound of formula I

wherein

-   R is hydrogen or methoxy; -   Q is

wherein

-   R₁ is hydrogen, halogen or C₁-C₆alkyl; -   R₂ is hydrogen, halogen, C₁-C₆alkyl, C₂-C₆alkenyl, C₃-C₆alkinyl,     C₃-C₆cycloalkyl-C₃-C₆alkinyl, halophenoxy, halophenyl-C₃-C₆alkinyl,     C(C₁-C₄alkyl)=NO—C₁-C₄alkyl, C₁-C₆haloalkyl, C₁-C₆haloalkoxy,     C₂-C₆haloalkenyl, or C₂-C₆haloalkenyloxy; -   R₃ is hydrogen, halogen or C₁-C₆alkyl; with the proviso that at     least one of R₁, R₂ and R₃ is different from hydrogen; -   R₄, R₅ and R₆, independently from each other, are hydrogen, halogen     or —≡—R₇; with the proviso that at least one of R₄, R₅ and R₆ is     different from hydrogen; -   R₇ is hydrogen, C₁-C₆alkyl, C₁-C₆haloalkyl or C₁-C₄alkoxyalkyl; and -   R₈ is hydrogen or methoxy; -   and agrochemically acceptable salts, stereoisomers,     diastereoisomers, enantiomers and tautomers of those compounds;     and     as component (B) a compound selected from the group consisting of -   azoxystrobin (47), dimoxystrobin (226), fluoxastrobin (382),     kresoxim-methyl (485), metominostrobin (551), orysastrobin,     picoxystrobin (647), pyraclostrobin (690), trifloxystrobin (832), a     compound of formula B-1.1

azaconazole (40), bromuconazole (96), cyproconazole (207), difenoconazole (247), diniconazole (267), diniconazole-M (267), epoxiconazole (298), fenbuconazole (329), fluquinconazole (385), flusilazole (393), flutriafol (397), hexaconazole (435), imazalil (449), imibenconazole (457), ipconazole (468), metconazole (525), myclobutanil (564), oxpoconazole (607), pefurazoate (618), penconazole (619), prochloraz (659), propiconazole (675), prothioconazole (685), simeconazole (731), tebuconazole (761), tetraconazole (778), triadimefon (814), triadimenol (815), triflumizole (834), triticonazole (842), diclobutrazol (1068), etaconazole (1129), furconazole (1198), furconazole-cis (1199) and quinconazole (1378); aldimorph (CAS Reg. No. 91315-15-0), dodemorph (288), fenpropimorph (344), tridemorph (830), fenpropidin (343), spiroxamine (740), piperalin (648), a compound of formula B-3.1

cyprodinil (208), mepanipyrim (508), pyrimethanil (705), anilazine (878), benalaxyl (56), benalaxyl-M, benodanil (896), benomyl (62), benthiavalicarb, benthiavalicarb-isopropyl (68), biphenyl (81), bitertanol (84), blasticidin-S (85), bordeaux mixture (87), boscalid (88), bupirimate (98), cadmium chloride, captafol (113), captan (114), carbendazim (116), carbon disulfide (945), carboxin (120), carpropamid (122), cedar leaf oil, chinomethionat (126), chloroneb (139), chlorothalonil (142), chlozolinate (149), cinnamaldehyde, copper, copper ammoniumcarbonate, copper hydroxide (169), copper octanoate (170), copper oleate, copper sulphate (87), cyazofamid (185), cycloheximide (1022), cymoxanil (200), dichlofluanid (230), dichlone (1052), dichloropropene (233), diclocymet (237), diclomezine (239), dicloran (240), diethofencarb (245), diflumetorim (253), dimethirimol (1082), dimethomorph (263), dinocap (270), dithianon (279), dodine (289), edifenphos (290), ethaboxam (304), ethirimol (1133), etridiazole (321), famoxadone (322), fenamidone (325), fenaminosulf (1144), fenamiphos (326), fenarimol (327), fenfuram (333), fenhexamid (334), fenoxanil (338), fenpiclonil (341), fentin acetate (347), fentin chloride, fentin hydroxide (347), ferbam (350), ferimzone (351), fluazinam (363), fludioxonil (368), flusulfamide (394), flutolanil (396), folpet (400), formaldehyde (404), fosetyl-aluminium (407), fthalide (643), fuberidazole (419), furalaxyl (410), furametpyr (411), flyodin (1205), fuazatine (422), hexachlorobenzene (434), hymexazole, iminoctadine tris(albesliate) (CAS Reg. No: 99257-43-9), iodocarb (3-Iodo-2-propynyl butyl carbamate), iprobenfos (IBP) (469), iprodione (470), iprovalicarb (471), isoprothiolane (474), kasugamycin (483), mancozeb (496), maneb (497), manganous dimethyldithiocarbamate, mefenoxam (Metalaxyl-M) (517), mepronil (510), mercuric chloride (511), mercury, metalaxyl (516), methasulfocarb (528), metiram (546), metrafenone, nabam (566), neem oil (hydrophobic extract), nuarimol (587), octhilinone (590), ofurace (592), oxadixyl (601), oxine copper (605), oxolinic acid (606), oxycarboxin (608), oxytetracycline (611), paclobutrazole (612), paraffin oil (628), paraformaldehyde, pencycuron (620), pentachloronitrobenzene (716), pentachlorophenol (623), penthiopyrad, perfurazoate, phosphoric acid, polyoxin (654), polyoxin D zinc salt (654), potassium bicarbonate, probenazole (658), procymidone (660), propamocarb (668), propineb (676), proquinazid (682), prothiocarb (1361), pyrazophos (693), pyrifenox (703), pyroquilon (710), quinoxyfen (715), quintozene (PCN(B) (716), silthiofam (729), sodium bicarbonate, sodium diacetate, sodium propionate, streptomycin (744), sulphur (754), TCMTB, tecloftalam, tecnazene (TCN(B) (767), thiabendazole (790), thifluzamide (796), thiophanate (1435), thiophanate-methyl (802), thiram (804), tolclofos-methyl (808), tolylfluanid (810), triazoxide (821), trichoderma harzianum (825), tricyclazole (828), triforine (838), triphenyltin hydroxide (347), validamycin (846), vinclozolin (849), zineb (855), ziram (856), zoxamide (857), 1,1-bis(4-chlorophenyl)-2-ethoxyethanol (IUPAC-Name) (910), 2,4-dichlorophenyl benzenesulfonate (IUPAC-/Chemical Abstracts-Name) (1059), 2-fluoro-N-methyl-N-1-naphthylacetamide (IUPAC-Name) (1295), 4-chlorophenyl phenyl sulfone (IUPAC-Name) (981), a compound of formula B-5.1

a compound of formula B-5.2

a compound of formula B-5.3

a compound of formula B-5.4

a compound of formula B-5.5

a compound of formula B-5.6

a compound of formula B-5.7

3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (2-bicyclopropyl-2-yl-phenyl)-amide (compound B-5.8), 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (9-isopropyl)-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-yl)-amide (compound B-5.9), 1,3-dimethyl-5-fluoro-1H-pyrazole-4-carboxylic acid [2-(1,3-dimethylbutyl)phenyl]-amide (compound B-5.10), 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (3′,4′-dichloro-5-fluoro-1,1′-biphenyl-2-yl)-amide (compound B-5.11, bixafen), N-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethyl}-2-(trifluoromethyl)benzamid (compound B-5.12, fluopyram), 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid N-[2-(1,1,2,2-tetrafluoroethoxy)phenyl]-amide (compound B-5.13), 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid N-[2-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]-amide (compound B-5.14), 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid N-[2-(2-chloro-1,1,2-trifluoroethoxy)phenyl]-amide (compound B-5.15), 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid N-(4′-trifluoromethyl-biphen-2-yl)-amide (compound B-5.16), 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid N-(2′-trifluoromethyl-biphen-2-yl)-amide (compound B-5.17) and 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid N-(2′-trifluoromethyl-biphen-2-yl)-amide (compound B-5.18), acibenzolar-S-methyl (6), chlormequat chloride (137), ethephon (307), mepiquat chloride (509) and trinexapac-ethyl (841), abamectin (1), clothianidin (165), emamectin benzoate (291), imidacloprid (458), tefluthrin (769), thiamethoxam (792), glyphosate (419), a compound of formula V

fomesafen, isopyrazam, sedaxane, the compound of formula (VI)

the compound of formula (VII)

1-[4-[4-[(5S)5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl]piperidin-1-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone, 1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl]piperidin-1-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone, fluxapyroxad, phosphorous acid, phosphorous acid sodium salt and phosphorous acid ammonium salt; and as component (C) a compound selected from the group consisting of

-   the compound of formula VII, fluxapyroxad, bixafen, penthiopyrad,     fluopyram, boscalid, isopyrazam, propiconazole, cyproconazole,     difenoconazole, prothioconazole, thiabendazole azoxystrobin,     thiophanate methyl, iminoctadine tris(albesilate), tebuconazole,     pyraclostrobin, trifloxystrobin, fludioxonil, cyprodinil and     fluazinam; with the exception of the mixtures comprising a compound     of formula I+azoxystrobin+cyproconazole and     with the proviso that in each composition component (B) is different     from component (C).

According to the present invention, preferred salts of glyphosate are the potassium, isopropylammonium, sodium, trimesium, ammonium and diammonium salts. Preferred salts of glufosinate are disclosed in U.S. Pat. No. 4,168,963, a preferred salt is the ammonium salt.

The compounds of formula I wherein R₈ is hydrogen can occur in the two enantiomeric forms of formula Ia and Ib:

The invention encompasses both enantiomeric forms of the compounds of formula I. The compounds of formula I and their preparation are described in WO 2010/063700, WO 2010/084078 and WO 2008/151828.

It has been found that the use of components (B) and (C) in combination with component (A) surprisingly and substantially may enhance the effectiveness of the latter against fungi, and vice versa. Additionally, the method of the invention is effective against a wider spectrum of such fungi that can be combated with the active ingredients of this method, when used solely.

In general, the weight ratio of component (A) to the mixture of components (B) and (C) is from 1000:1 to 1:1000, especially from 50:1 to 1:50, more especially in a ratio of from 20:1 to 1:20, even more especially from 10:1 to 1:10, very especially from 5:1 and 1:5, special preference being given to a ratio of from 2:1 to 1:2, and a ratio of from 4:1 to 2:1 being likewise preferred, above all in a ratio of 1:1, or 5:1, or 5:2, or 5:3, or 5:4, or 4:1, or 4:2, or 4:3, or 3:1, or 3:2, or 2:1, or 1:5, or 2:5, or 3:5, or 4:5, or 1:4, or 2:4, or 3:4, or 1:3, or 2:3, or 1:2, or 1:600, or 1:300, or 1:150, or 1:35, or 2:35, or 4:35, or 1:75, or 2:75, or 4:75, or 1:6000, or 1:3000, or 1:1500, or 1:350, or 2:350, or 4:350, or 1:750, or 2:750, or 4:750. Those mixing ratios are understood to include, on the one hand, ratios by weight and also, on other hand, molar ratios.

In a preferred embodiment of the invention, the ratios by weight of component (A) to the mixture of components (B) and (C) are 4:1 to 1:4.

In a preferred embodiment of the invention, ratios by weight of component (B) to component (C) are from 2:1 to 1:6.

It has been found, surprisingly, that certain weight ratios of component (A) to the mixture of component (B) and (C) are able to give rise to synergistic activity. Therefore, a further aspect of the invention are compositions, wherein component (A) and the mixture of component (B) and (C) are present in the composition in amounts producing a synergistic effect. This synergistic activity is apparent from the fact that the fungicidal activity of the composition comprising component (A) the mixture of component (B) and (C) is greater than the sum of the fungicidal activities of component (A) and of the mixture of component (B) and (C). This synergistic activity extends the range of action of component (A) and the mixture of component (B) and (C) in two ways. Firstly, the rates of application of component (A) and the mixture of component (B) and (C) are lowered whilst the action remains equally good, meaning that the active ingredient mixture still achieves a high degree of phytopathogen control even where the two individual components have become totally ineffective in such a low application rate range. Secondly, there is a substantial broadening of the spectrum of phytopathogens that can be controlled.

A synergistic effect exists whenever the action of an active ingredient combination is greater than the sum of the actions of the individual components. The action to be expected E for a given active ingredient combination obeys the so-called COLBY formula and can be calculated as follows (COLBY, S. R. “Calculating synergistic and antagonistic responses of herbicide combination”. Weeds, Vol. 15, pages 20-22; 1967):

-   ppm=milligrams of active ingredient (=a.i.) per liter of spray     mixture -   X=% action by active ingredient (A) using p ppm of active ingredient -   Y=% action by active ingredients (B+C) using q ppm of active     ingredient.     Or: -   X=% action by active ingredient (A+B) using p ppm of active     ingredient -   Y=% action by active ingredient (C) using q ppm of active     ingredient.     Or: -   X=% action by active ingredient (A+C) using p ppm of active     ingredient -   Y=% action by active ingredient (B) using q ppm of active     ingredient.

According to COLBY, the expected (additive) action of active ingredients (A)+(B+C) or (A+B)+(C) or (A+C)+(B) using p+q ppm of active ingredient is

$E = {X + Y - \frac{X \cdot Y}{100}}$

If the action actually observed (O) is greater than the expected action (E), then the action of the combination is super-additive, i.e. there is a synergistic effect. In mathematical terms, synergism corresponds to a positive value for the difference of (O−E). In the case of purely complementary addition of activities (expected activity), said difference (O−E) is zero. A negative value of said difference (O−E) signals a loss of activity compared to the expected activity.

Synergism can also be calculated by using the following formula: E(expected value)=X+Y+Z−[(XY)+(XZ)+(YZ)/100]+[XYZ/10000] X, Y, Z=% action by active ingredient (A), (B) and (C) alone using p ppm of active ingredient.

However, besides the actual synergistic action with respect to fungicidal activity, the compositions according to the invention can also have further surprising advantageous properties. Examples of such advantageous properties that may be mentioned are: more advantageous degradability; improved toxicological and/or ecotoxicological behaviour; or improved characteristics of the useful plants including: emergence, crop yields, more developed root system, tillering increase, increase in plant height, bigger leaf blade, less dead basal leaves, stronger tillers, greener leaf colour, less fertilizers needed, less seeds needed, more productive tillers, earlier flowering, early grain maturity, less plant verse (lodging), increased shoot growth, improved plant vigor, and early germination.

Some compositions according to the invention have a systemic action and can be used as foliar, soil and seed treatment fungicides.

With the compositions according to the invention it is possible to inhibit or destroy the phytopathogenic microorganisms which occur in plants or in parts of plants (fruit, blossoms, leaves, stems, tubers, roots) in different useful plants, while at the same time the parts of plants which grow later are also protected from attack by phytopathogenic microorganisms.

The compositions according to the invention can be applied to the phytopathogenic microorganisms, the useful plants, the locus thereof, the propagation material thereof, storage goods or technical materials threatened by microorganism attack.

The compositions according to the invention may be applied before or after infection of the useful plants, the propagation material thereof, storage goods or technical materials by the microorganisms.

A further aspect of the present invention is a method of controlling diseases on useful plants or on propagation material thereof caused by phytopathogens, which comprises applying to the useful plants, the locus thereof or propagation material thereof a composition according to the invention. Preferred is a method, which comprises applying to the useful plants or to the locus thereof a composition according to the invention, more preferably to the useful plants. Further preferred is a method, which comprises applying to the propagation material of the useful plants a composition according to the invention.

The components (B) and (C) are known. Where the components (B) and (C) are included in “The Pesticide Manual” [The Pesticide Manual—A World Compendium; Thirteenth Edition; Editor: C. D. S. Tomlin; The British Crop Protection Council], they are described therein under the entry number given in round brackets hereinabove for the particular component (B) and (C); for example, the compound “abamectin” is described under entry number (1). Most of the components (B) and (C) are referred to hereinabove by a so-called “common name”, the relevant “ISO common name” or another “common name” being used in individual cases. If the designation is not a “common name”, the nature of the designation used instead is given in round brackets for the particular component (B) and (C) respectively; in that case, the IUPAC name, the IUPAC/Chemical Abstracts name, a “chemical name”, a “traditional name”, a “compound name” or a “development code” is used or, if neither one of those designations nor a “common name” is used, an “alternative name” is employed.

The following components (B) and (C) are registered under a CAS-Reg. No. aldimorph (CAS 91315-15-0); arsenates (CAS 1327-53-3); benalaxyl-M (CAS 98243-83-5); benthiavalicarb (CAS 413615-35-7); cadmium chloride (CAS 10108-64-2); cedar leaf oil (CAS 8007-20-3); cinnamaldehyde (CAS: 104-55-2); copper ammoniumcarbonate (CAS 33113-08-5); copper oleate (CAS 1120-44-1); iodocarb (3-Iodo-2-propynyl butyl carbamate) (CAS 55406-53-6); hymexazole (CAS 10004-44-1); manganous dimethyldithiocarbamate (CAS 15339-36-3); mercury (CAS 7487-94-7; 21908-53-2; 7546-30-7); metrafenone (CAS 220899-03-6); neem oil (hydrophobic extract) (CAS 8002-65-1); orysastrobin CAS 248593-16-0); paraformaldehyde (CAS 30525-89-4); penthiopyrad (CAS 183675-82-3); phosphoric acid (CAS 7664-38-2); potassium bicarbonate (CAS 298-14-6); sodium bicarbonate (CAS 144-55-8); sodium diacetate (CAS 127-09-3); sodium propionate (CAS 137-40-6); TCMTB (CAS 21564-17-0); and tolyfluanid (CAS 731-27-1).

Compound B-1.1 (“enestrobin”) is described in EP-0-936-213; compound B-3.1 (“flumorph”) in U.S. Pat. No. 6,020,332, CN-1-167-568, CN-1-155-977 and in EP-0-860-438; compound B-5.1 (“mandipropamid”) in WO 01/87822; compound B-5.2 in WO 98/46607; compound B-5.3 (“fluopicolide”) in WO 99/42447; compound B-5.4 (“cyflufenamid”) in WO 96/19442; compound B-5.5 in WO 99/14187; compound B-5.6 (“pyribencarb”) is registered under CAS-Reg. No. 325156-49-8; compound B-5.7 (“amisulbrom” or “ambromdole”) is registered under CAS-Reg. No. 348635-87-0; compound B-5.8 (3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (2-bicyclopropyl-2-yl-phenyl)-amide) is described in WO 03/74491; compound B-5.9 (3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (9-isopropyl)-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-yl)-amide) is described in WO 04/35589 and in WO 06/37632; compound B-5.10 (1,3-dimethyl-5-fluoro-1H-pyrazole-4-carboxylic acid [2-(1,3-dimethylbutyl)phenyl]-amide) is described in WO 03/10149; compound B-5.11 (3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (3′,4′-dichloro-5-fluoro-1,1′-biphenyl-2-yl)-amide; “bixafen”) is registered under CAS-Reg. No.: 581809-46-3 and described in WO 03/70705; compound B-5.12 (N-{2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]ethyl}-2-(trifluoromethyl)benzamid; “fluopyram”) is registered under CAS-Reg. No: 658066-35-4 and described in WO 04/16088; compounds B-5.13, B-5.14 and B-5.15 are described in WO 2007/17450; compounds B-5.16, B-5.17 and B-5.18 are described in WO 2006/120219. The compound of formula B-7.1 is described in WO 03/015519, the compound of formula B-7.2 is described in WO 2004/067528, the compound of formula B-7.3 is described in WO 2007/115644. The compound of formula V is described in WO 2001/094339. Isopyrazam (3-(difluoromethyl)-1-methyl-N-[1,2,3,4-tetrahydro-9-(1-methylethyl)-1,4-methanonaphthalen-5-yl]-1H-pyrazole-4-carboxamide) is described in WO 2004/035589, in WO 2006/037632 and in EP 1556385 and is registered under the CAS-Reg. 881685-58-1. Sedaxane (N-[2-[1,1′-bicyclopropyl]-2-ylphenyl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide) is described in WO 2003/074491 and is registered under the CAS-Reg. 874967-67-6; The compound of formula (VI) is described in WO 2008/014870; and the compounds of formula (VII) (solatenol, 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (9-dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-yl)-amide) is described in WO 2007/048556. Fomesafen is registered under the CAS-Reg. No. 72178-02-0. 1-[4-[4-[(5S)5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl]piperidin-1-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone and 1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl]piperidin-1-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone (CAS-Reg. No.: 1003318-67-9) are both disclosed in WO 2010/123791, WO 2008/013925, WO 2008/013622 and WO 2011/051243 page 20), 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (3′,4′,5′-trifluoro-biphenyl-2-yl)-amide (fluxapyroxad) is disclosed in WO 2006/087343.

Throughout this document the expression “composition” means the various mixtures or combinations of components (A) and the mixture of (B) and (C), for example in a single “ready-mix” form, in a combined spray mixture composed from separate formulations of the single active ingredient components, such as a “tank-mix”, and in a combined use of the single active ingredients when applied in a sequential manner, i.e. one after the other with a reasonably short period, such as a few hours or days. The order of applying the components (A) and (B) and (C) is not essential for working the present invention.

As components (A) are compounds of formula I preferred, wherein Q is Q₁, wherein R₁. R₂ and R₃ are preferably halogen, in particular chloro; R is methoxy and R₈ is hydrogen.

Preferred components (A) are listed in the following Table 1:

TABLE 1 Compounds of formula Ic:

(Ic) wherein Q is

(Q₁)

(Q₂) Compound No. R₁ R₂ R₃ Q R₄ R₅ R₆ R₈ 1.001 Cl Cl Cl Q₁ — — — H 1.002 Cl H Cl Q₁ — — — H 1.003 Cl Cl H Q₁ — — — H 1.004 Cl Br Cl Q₁ — — — H 1.005 Br Br Br Q₁ — — — H 1.006 H Cl H Q₁ — — — H 1.007 H Br H Q₁ — — — H 1.008 H CF₃ H Q₁ — — — H 1.009 — — — Q₂ Cl Cl Cl H 1.010 — — — Q₂ Cl H Cl H 1.011 — — — Q₂ H Cl Cl H 1.012 — — — Q₂ Cl Cl Br H 1.013 — — — Q₂ Cl H Br H 1.014 — — — Q₂ H Cl Br H 1.015 — — — Q₂ H Cl H H 1.016 — — — Q₂ Cl H H H 1.017 Cl Cl Cl Q₁ — — — OCH₃ 1.018 Cl H Cl Q₁ — — — OCH₃ 1.019 Cl Cl H Q₁ — — — OCH₃ 1.020 Cl Br Cl Q₁ — — — OCH₃ 1.021 Br Br Br Q₁ — — — OCH₃ 1.022 H Cl H Q₁ — — — OCH₃ 1.023 H Br H Q₁ — — — OCH₃ 1.024 H CF₃ H Q₁ — — — OCH₃ 1.025 — — — Q₂ Cl Cl Cl OCH₃ 1.026 — — — Q₂ Cl H Cl OCH₃ 1.027 — — — Q₂ H Cl Cl OCH₃ 1.028 — — — Q₂ Cl Cl Br OCH₃ 1.029 — — — Q₂ Cl H Br OCH₃ 1.030 — — — Q₂ H Cl Br OCH₃ 1.031 — — — Q₂ H Cl H OCH₃ 1.032 — — — Q₂ Cl H H OCH₃

Further preferred components (A) are listed in the following Table 2:

TABLE 2 Compounds of formula Id:

(Id) wherein Q is

(Q₁)

(Q₂) Compound No. R₁ R₂ R₃ Q R₄ R₅ R₆ R₈ 2.001 Cl Cl Cl Q₁ — — — H 2.002 Cl H Cl Q₁ — — — H 2.003 Cl Cl H Q₁ — — — H 2.004 Cl Br Cl Q₁ — — — H 2.005 Br Br Br Q₁ — — — H 2.006 H Cl H Q₁ — — — H 2.007 H Br H Q₁ — — — H 2.008 H CF₃ H Q₁ — — — H 2.009 — — — Q₂ Cl Cl Cl H 2.010 — — — Q₂ Cl H Cl H 2.011 — — — Q₂ H Cl Cl H 2.012 — — — Q₂ Cl Cl Br H 2.013 — — — Q₂ Cl H Br H 2.014 — — — Q₂ H Cl Br H 2.015 — — — Q₂ H Cl H H 2.016 — — — Q₂ Cl H H H 2.017 Cl Cl Cl Q₁ — — — OCH₃ 2.018 Cl H Cl Q₁ — — — OCH₃ 2.019 Cl Cl H Q₁ — — — OCH₃ 2.020 Cl Br Cl Q₁ — — — OCH₃ 2.021 Br Br Br Q₁ — — — OCH₃ 2.022 H Cl H Q₁ — — — OCH₃ 2.023 H Br H Q₁ — — — OCH₃ 2.024 H CF₃ H Q₁ — — — OCH₃ 2.025 — — — Q₂ Cl Cl Cl OCH₃ 2.026 — — — Q₂ Cl H Cl OCH₃ 2.027 — — — Q₂ H Cl Cl OCH₃ 2.028 — — — Q₂ Cl Cl Br OCH₃ 2.029 — — — Q₂ Cl H Br OCH₃ 2.030 — — — Q₂ H Cl Br OCH₃ 2.031 — — — Q₂ H Cl H OCH₃ 2.032 — — — Q₂ Cl H H OCH₃

The following binary mixtures of components (A) with components (B) are preferred and are defined as members of the group P (the abbreviation “TX” means: “one compound selected from the group consisting of the compounds specifically described in Tables 1 and 2 of the present invention”):

Group P:

azoxystrobin (47)+TX, dimoxystrobin (226)+TX, fluoxastrobin (382)+TX, kresoxim-methyl (485)+TX, metominostrobin (551)+TX, orysastrobin+TX, picoxystrobin (647)+TX, pyraclostrobin (690), trifloxystrobin (832)+TX, a compound of formula B-1.1+TX

azaconazole (40)+TX, bromuconazole (96)+TX, cyproconazole (207)+TX, difenoconazole (247)+TX, diniconazole (267)+TX, diniconazole-M (267)+TX, epoxiconazole (298)+TX, fenbuconazole (329)+TX, fluquinconazole (385)+TX, flusilazole (393)+TX, flutriafol (397)+TX, hexaconazole (435)+TX, imazalil (449)+TX, imibenconazole (457)+TX, ipconazole (468)+TX, metconazole (525)+TX, myclobutanil (564)+TX, oxpoconazole (607)+TX, pefurazoate (618)+TX, penconazole (619)+TX, prochloraz (659)+TX, propiconazole (675)+TX, prothioconazole (685)+TX, simeconazole (731)+TX, tebuconazole (761)+TX, tetraconazole (778)+TX, triadimefon (814)+TX, triadimenol (815)+TX, triflumizole (834)+TX, triticonazole (842)+TX, diclobutrazol (1068)+TX, etaconazole (1129)+TX, furconazole (1198)+TX, furconazole-cis (1199)+TX, quinconazole (1378)+TX, aldimorph+TX, dodemorph (288)+TX, fenpropimorph (344)+TX, tridemorph (830)+TX, fenpropidin (343)+TX, spiroxamine (740)+TX, piperalin (648)+TX, a compound of formula B-3.1

+TX, cyprodinil (208)+TX, mepanipyrim (508)+TX, pyrimethanil (705)+TX; anilazine (878)+TX, arsenates+TX, benalaxyl (56)+TX, benalaxyl-M+TX, benodanil (896)+TX, benomyl (62)+TX, benthiavalicarb+TX, benthiavalicarb-isopropyl (68)+TX, biphenyl (81)+TX, bitertanol (84)+TX, blasticidin-S (85)+TX, bordeaux mixture (87)+TX, boscalid (88)+TX, bupirimate (98)+TX, cadmium chloride+TX, captafol (113)+TX, captan (114)+TX, carbendazim (116)+TX, carbon disulfide (945)+TX, carboxin (120)+TX, carpropamid (122)+TX, cedar leaf oil+TX, chinomethionat (126)+TX, chloroneb (139)+TX, chlorothalonil (142)+TX, chlozolinate (149)+TX, cinnamaldehyde+TX, copper+TX, copper ammoniumcarbonate+TX, copper hydroxide (169)+TX, copper octanoate (170)+TX, copper oleate+TX, copper sulphate (87)+TX, cyazofamid (185)+TX, cycloheximide (1022)+TX, cymoxanil (200)+TX, dichlofluanid (230)+TX, dichlone (1052)+TX, dichloropropene (233)+TX, diclocymet (237)+TX, diclomezine (239)+TX, dicloran (240)+TX, diethofencarb (245)+TX, diflumetorim (253)+TX, dimethirimol (1082)+TX, dimethomorph (263)+TX, dinocap (270)+TX, dithianon (279)+TX, dodine (289)+TX, edifenphos (290)+TX, ethaboxam (304)+TX, ethirimol (1133)+TX, etridiazole (321)+TX, famoxadone (322)+TX, fenamidone (325)+TX, fenaminosulf (1144)+TX, fenamiphos (326)+TX, fenarimol (327)+TX, fenfuram (333)+TX, fenhexamid (334)+TX, fenoxanil (338)+TX, fenpiclonil (341)+TX, fentin acetate (347)+TX, fentin chloride+TX, fentin hydroxide (347)+TX, ferbam (350)+TX, ferimzone (351)+TX, fluazinam (363)+TX, fludioxonil (368)+TX, flusulfamide (394)+TX, flutolanil (396)+TX, folpet (400)+TX, formaldehyde (404)+TX, fosetyl-aluminium (407)+TX, fthalide (643)+TX, fuberidazole (419)+TX, furalaxyl (410)+TX, furametpyr (411)+TX, flyodin (1205)+TX, fuazatine (422)+TX, hexachlorobenzene (434)+TX, hymexazole+TX, iminoctadine tris(albesliate) [99257-43-9]+TX, iodocarb (3-Iodo-2-propynyl butyl carbamate)+TX, iprobenfos (IBP) (469)+TX, iprodione (470)+TX, iprovalicarb (471)+TX, isoprothiolane (474)+TX, kasugamycin (483)+TX, mancozeb (496)+TX, maneb (497)+TX, manganous dimethyldithiocarbamate+TX, mefenoxam (Metalaxyl-M) (517)+TX, mepronil (510)+TX, mercuric chloride (511)+TX, mercury+TX, metalaxyl (516)+TX, methasulfocarb (528)+TX, metiram (546)+TX, metrafenone+TX, nabam (566)+TX, neem oil (hydrophobic extract)+TX, nuarimol (587)+TX, octhilinone (590)+TX, ofurace (592)+TX, oxadixyl (601)+TX, oxine copper (605)+TX, oxolinic acid (606)+TX, oxycarboxin (608)+TX, oxytetracycline (611)+TX, paclobutrazole (612)+TX, paraffin oil (628)+TX, paraformaldehyde+TX, pencycuron (620)+TX, pentachloronitrobenzene (716)+TX, pentachlorophenol (623)+TX, penthiopyrad+TX, perfurazoate+TX, phosphoric acid+TX, polyoxin (654)+TX, polyoxin D zinc salt (654)+TX, potassium bicarbonate+TX, probenazole (658)+TX, procymidone (660)+TX, propamocarb (668)+TX, propineb (676)+TX, proquinazid (682)+TX, prothiocarb (1361)+TX, pyrazophos (693)+TX, pyrifenox (703)+TX, pyroquilon (710)+TX, quinoxyfen (715)+TX, quintozene (PCN(B) (716)+TX, silthiofam (729)+TX, sodium bicarbonate+TX, sodium diacetate+TX, sodium propionate+TX, streptomycin (744)+TX, sulphur (754)+TX, TCMTB+TX, tecloftalam+TX, tecnazene (TCN(B) (767)+TX, thiabendazole (790)+TX, thifluzamide (796)+TX, thiophanate (1435)+TX, thiophanate-methyl (802)+TX, thiram (804)+TX, tolclofos-methyl (808)+TX, tolylfluanid (810)+TX, triazoxide (821)+TX, trichoderma harzianum (825)+TX, tricyclazole (828)+TX, triforine (838)+TX, triphenyltin hydroxide (347)+TX, validamycin (846)+TX, vinclozolin (849)+TX, zineb (855)+TX, ziram (856)+TX, zoxamide (857)+TX, 1+TX, 1-bis(4-chlorophenyl)-2-ethoxyethanol (IUPAC-Name) (910)+TX, 2,4-dichlorophenyl benzenesulfonate (IUPAC-/Chemical Abstracts-Name) (1059)+TX, 2-fluoro-N-methyl-N-1-naphthylacetamide (IUPAC-Name) (1295)+TX, 4-chlorophenyl phenyl sulfone (IUPAC-Name) (981)+TX, a compound of formula B-5.1+TX, a compound of formula B-5.2+TX, a compound of formula B-5.3+TX, a compound of formula B-5.4+TX, a compound of formula B-5.5+TX, a compound of formula B-5.6+TX, a compound of formula B-5.7+TX, compound B-5.8+TX, compound B-5.9+TX, compound B-5.10+TX, bixafen+TX, fluopyram+TX, compound B-5.13+TX, compound B-5.14+TX, compound B-5.15+TX, compound B-5.16+TX, compound B-5.17+TX and compound B-5.18+TX, acibenzolar-S-methyl (6)+TX, chlormequat chloride (137)+TX, ethephon (307)+TX, mepiquat chloride (509)+TX, trinexapac-ethyl (841)+TX, abamectin (1)+TX, clothianidin (165)+TX, emamectin benzoate (291)+TX, imidacloprid (458)+TX, tefluthrin (769)+TX, thiamethoxam (792)+TX, and glyphosate (419)+TX, a compound of formula V

fomesafen+TX, isopyrazam+TX, sedaxane+TX, the compound of formula (VI)+TX

the compound of formula (VII)+TX

1-[4-[4-[(5S)5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl]piperidin-1-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone+TX, 1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl]piperidin-1-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone+TX, fluxapyroxad+TX, phosphorous acid+TX, phosphorous acid sodium salt+TX and phosphorous acid ammonium salt+TX.

Especially preferred compositions according to the present invention are defined in the following Table 3 as embodiments E1 to E21. The term TX1 means “one mixture selected from the group P”. The compositions wherein component (B) from the group P is identical to component (C) are excluded. The compositions comprising a compound of formula I according to tables 1 and 2+azoxystrobin+cyproconazole are excluded.

TABLE 3 preferred mixtures according to this invention: Embodiment Component C E1 compound of formula VII + TX1 E2 fluxapyroxad + TX1 E3 bixafen + TX1 E4 penthiopyrad + TX1 E5 fluopyram + TX1 E6 boscalid + TX1 E7 isopyrazam + TX1 E8 propiconazole + TX1 E9 cyproconazole + TX1 E10 difenoconazole + TX1 E11 prothioconazole + TX1 E12 iminoctadine tris(albesilate) + TX1 E13 thiabendazole + TX1 E14 azoxystrobin + TX1 E15 thiophanate methyl + TX1 E16 tebuconazole + TX1 E17 trifloxystrobin + TX1 E18 pyraclostrobin + TX1 E19 fludioxonil + TX1 E20 cyprodinil + TX1 E21 fluazinam + TX1

For example, embodiment E1 consists of the following ternary mixtures:

-   azoxystrobin (47)+TX+the compound of formula VII, dimoxystrobin     (226)+TX+the compound of formula VII, fluoxastrobin (382)+TX+the     compound of formula VII, kresoxim-methyl (485)+TX+the compound of     formula VII, metominostrobin (551)+TX+the compound of formula VII,     orysastrobin+TX+the compound of formula VII, picoxystrobin     (647)+TX+the compound of formula VII, pyraclostrobin (690)+TX+the     compound of formula VII, trifloxystrobin (832)+TX+the compound of     formula VII, a compound of formula B-1.1

+TX+the compound of formula VII, azaconazole (40)+TX+the compound of formula VII, bromuconazole (96)+TX+the compound of formula VII, cyproconazole (207)+TX+the compound of formula VII, difenoconazole (247)+TX+the compound of formula VII, diniconazole (267)+TX+the compound of formula VII, diniconazole-M (267)+TX+the compound of formula VII, epoxiconazole (298)+TX+the compound of formula VII, fenbuconazole (329)+TX+the compound of formula VII, fluquinconazole (385)+TX+the compound of formula VII, flusilazole (393)+TX+the compound of formula VII, flutriafol (397)+TX+the compound of formula VII, hexaconazole (435)+TX+the compound of formula VII, imazalil (449)+TX+the compound of formula VII, imibenconazole (457)+TX+the compound of formula VII, ipconazole (468)+TX+the compound of formula VII, metconazole (525)+TX+the compound of formula VII, myclobutanil (564)+TX+the compound of formula VII, oxpoconazole (607)+TX+the compound of formula VII, pefurazoate (618)+TX+the compound of formula VII, penconazole (619)+TX+the compound of formula VII, prochloraz (659)+TX+the compound of formula VII, propiconazole (675)+TX+the compound of formula VII, prothioconazole (685)+TX+the compound of formula VII, simeconazole (731)+TX+the compound of formula VII, tebuconazole (761)+TX+the compound of formula VII, tetraconazole (778)+TX+the compound of formula VII, triadimefon (814)+TX+the compound of formula VII, triadimenol (815)+TX+the compound of formula VII, triflumizole (834)+TX+the compound of formula VII, triticonazole (842)+TX+the compound of formula VII, diclobutrazol (1068)+TX+the compound of formula VII, etaconazole (1129)+TX+the compound of formula VII, furconazole (1198)+TX+the compound of formula VII, furconazole-cis (1199)+TX+the compound of formula VII, quinconazole (1378)+TX+the compound of formula VII, aldimorph+TX+the compound of formula VII, dodemorph (288)+TX+the compound of formula VII, fenpropimorph (344)+TX+the compound of formula VII, tridemorph (830)+TX+the compound of formula VII, fenpropidin (343)+TX+the compound of formula VII, spiroxamine (740)+TX+the compound of formula VII, piperalin (648)+TX+the compound of formula VII, a compound of formula B-3.1

+TX+the compound of formula VII, cyprodinil (208)+TX+the compound of formula VII, mepanipyrim (508)+TX+the compound of formula VII, pyrimethanil (705)+TX+the compound of formula VII, anilazine (878)+TX+the compound of formula VII, arsenates+TX+the compound of formula VII, benalaxyl (56)+TX+the compound of formula VII, benalaxyl-M+TX+the compound of formula VII, benodanil (896)+TX+the compound of formula VII, benomyl (62)+TX+the compound of formula VII, benthiavalicarb+TX+the compound of formula VII, benthiavalicarb-isopropyl (68)+TX+the compound of formula VII, biphenyl (81)+TX+the compound of formula VII, bitertanol (84)+TX+the compound of formula VII, blasticidin-S (85)+TX+the compound of formula VII, bordeaux mixture (87)+TX+the compound of formula VII, boscalid (88)+TX+the compound of formula VII, bupirimate (98)+TX+the compound of formula VII, cadmium chloride+TX+the compound of formula VII, captafol (113)+TX+the compound of formula VII, captan (114)+TX+the compound of formula VII, carbendazim (116)+TX+the compound of formula VII, carbon disulfide (945)+TX+the compound of formula VII, carboxin (120)+TX+the compound of formula VII, carpropamid (122)+TX+the compound of formula VII, cedar leaf oil+TX+the compound of formula VII, chinomethionat (126)+TX+the compound of formula VII, chloroneb (139)+TX+the compound of formula VII, chlorothalonil (142)+TX+the compound of formula VII, chlozolinate (149)+TX+the compound of formula VII, cinnamaldehyde+TX+the compound of formula VII, copper+TX+the compound of formula VII, copper ammoniumcarbonate+TX+the compound of formula VII, copper hydroxide (169)+TX+the compound of formula VII, copper octanoate (170)+TX+the compound of formula VII, copper oleate+TX+the compound of formula VII, copper sulphate (87)+TX+the compound of formula VII, cyazofamid (185)+TX+the compound of formula VII, cycloheximide (1022)+TX+the compound of formula VII, cymoxanil (200)+TX+the compound of formula VII, dichlofluanid (230)+TX+the compound of formula VII, dichlone (1052)+TX+the compound of formula VII, dichloropropene (233)+TX+the compound of formula VII, diclocymet (237)+TX+the compound of formula VII, diclomezine (239)+TX+the compound of formula VII, dicloran (240)+TX+the compound of formula VII, diethofencarb (245)+TX+the compound of formula VII, diflumetorim (253)+TX+the compound of formula VII, dimethirimol (1082)+TX+the compound of formula VII, dimethomorph (263)+TX+the compound of formula VII, dinocap (270)+TX+the compound of formula VII, dithianon (279)+TX+the compound of formula VII, dodine (289)+TX+the compound of formula VII, edifenphos (290)+TX+the compound of formula VII, ethaboxam (304)+TX+the compound of formula VII, ethirimol (1133)+TX+the compound of formula VII, etridiazole (321)+TX+the compound of formula VII, famoxadone (322)+TX+the compound of formula VII, fenamidone (325)+TX+the compound of formula VII, fenaminosulf (1144)+TX+the compound of formula VII, fenamiphos (326)+TX+the compound of formula VII, fenarimol (327)+TX+the compound of formula VII, fenfuram (333)+TX+the compound of formula VII, fenhexamid (334)+TX+the compound of formula VII, fenoxanil (338)+TX+the compound of formula VII, fenpiclonil (341)+TX+the compound of formula VII, fentin acetate (347)+TX+the compound of formula VII, fentin chloride+TX+the compound of formula VII, fentin hydroxide (347)+TX+the compound of formula VII, ferbam (350)+TX+the compound of formula VII, ferimzone (351)+TX+the compound of formula VII, fluazinam (363)+TX+the compound of formula VII, fludioxonil (368)+TX+the compound of formula VII, flusulfamide (394)+TX+the compound of formula VII, flutolanil (396)+TX+the compound of formula VII, folpet (400)+TX+the compound of formula VII, formaldehyde (404)+TX+the compound of formula VII, fosetyl-aluminium (407)+TX+the compound of formula VII, fthalide (643)+TX+the compound of formula VII, fuberidazole (419)+TX+the compound of formula VII, furalaxyl (410)+TX+the compound of formula VII, furametpyr (411)+TX+the compound of formula VII, flyodin (1205)+TX+the compound of formula VII, fuazatine (422)+TX+the compound of formula VII, hexachlorobenzene (434)+TX+the compound of formula VII, hymexazole+TX+the compound of formula VII, iminoctadine tris(albesliate) (CAS Reg. No. 99257-43-9)+TX+the compound of formula VII, iodocarb (3-Iodo-2-propynyl butyl carbamate)+TX+the compound of formula VII, iprobenfos (IBP) (469)+TX+the compound of formula VII, iprodione (470)+TX+the compound of formula VII, iprovalicarb (471)+TX+the compound of formula VII, isoprothiolane (474)+TX+the compound of formula VII, kasugamycin (483)+TX+the compound of formula VII, mancozeb (496)+TX+the compound of formula VII, maneb (497)+TX+the compound of formula VII, manganous dimethyldithiocarbamate+TX+the compound of formula VII, mefenoxam (Metalaxyl-M) (517)+TX+the compound of formula VII, mepronil (510)+TX+the compound of formula VII, mercuric chloride (511)+TX+the compound of formula VII, mercury+TX+the compound of formula VII, metalaxyl (516)+TX+the compound of formula VII, methasulfocarb (528)+TX+the compound of formula VII, metiram (546)+TX+the compound of formula VII, metrafenone+TX+the compound of formula VII, nabam (566)+TX+the compound of formula VII, neem oil (hydrophobic extract)+TX+the compound of formula VII, nuarimol (587)+TX+the compound of formula VII, octhilinone (590)+TX+the compound of formula VII, ofurace (592)+TX+the compound of formula VII, oxadixyl (601)+TX+the compound of formula VII, oxine copper (605)+TX+the compound of formula VII, oxolinic acid (606)+TX+the compound of formula VII, oxycarboxin (608)+TX+the compound of formula VII, oxytetracycline (611)+TX+the compound of formula VII, paclobutrazole (612)+TX+the compound of formula VII, paraffin oil (628)+TX+the compound of formula VII, paraformaldehyde+TX+the compound of formula VII, pencycuron (620)+TX+the compound of formula VII, pentachloronitrobenzene (716)+TX+the compound of formula VII, pentachlorophenol (623)+TX+the compound of formula VII, penthiopyrad+TX+the compound of formula VII, perfurazoate+TX+the compound of formula VII, phosphoric acid+TX+the compound of formula VII, polyoxin (654)+TX+the compound of formula VII, polyoxin D zinc salt (654)+TX+the compound of formula VII, potassium bicarbonate+TX+the compound of formula VII, probenazole (658)+TX+the compound of formula VII, procymidone (660)+TX+the compound of formula VII, propamocarb (668)+TX+the compound of formula VII, propineb (676)+TX+the compound of formula VII, proquinazid (682)+TX+the compound of formula VII, prothiocarb (1361)+TX+the compound of formula VII, pyrazophos (693)+TX+the compound of formula VII, pyrifenox (703)+TX+the compound of formula VII, pyroquilon (710)+TX+the compound of formula VII, quinoxyfen (715)+TX+the compound of formula VII, quintozene (PCN(B) (716)+TX+the compound of formula VII, silthiofam (729)+TX+the compound of formula VII, sodium bicarbonate+TX+the compound of formula VII, sodium diacetate+TX+the compound of formula VII, sodium propionate+TX+the compound of formula VII, streptomycin (744)+TX+the compound of formula VII, sulphur (754)+TX+the compound of formula VII, TCMTB+TX+the compound of formula VII, tecloftalam+TX+the compound of formula VII, tecnazene (TCN(B) (767)+TX+the compound of formula VII, thiabendazole (790)+TX+the compound of formula VII, thifluzamide (796)+TX+the compound of formula VII, thiophanate (1435)+TX+the compound of formula VII, thiophanate-methyl (802)+TX+the compound of formula VII, thiram (804)+TX+the compound of formula VII, tolclofos-methyl (808)+TX+the compound of formula VII, tolylfluanid (810)+TX+the compound of formula VII, triazoxide (821)+TX+the compound of formula VII, trichoderma harzianum (825)+TX+the compound of formula VII, tricyclazole (828)+TX+the compound of formula VII, triforine (838)+TX+the compound of formula VII, triphenyltin hydroxide (347)+TX+the compound of formula VII, validamycin (846)+TX+the compound of formula VII, vinclozolin (849)+TX+the compound of formula VII, zineb (855)+TX+the compound of formula VII, ziram (856)+TX+the compound of formula VII, zoxamide (857)+TX+the compound of formula VII, 1+TX+the compound of formula VII, 1-bis(4-chlorophenyl)-2-ethoxyethanol (IUPAC-Name) (910)+TX+the compound of formula VII, 2+TX+the compound of formula VII, 2,4-dichlorophenyl benzenesulfonate (IUPAC-/Chemical Abstracts-Name) (1059)+TX+the compound of formula VII, 2-fluoro-N-methyl-N-1-naphthylacetamide (IUPAC-Name) (1295)+TX+the compound of formula VII, 4-chlorophenyl phenyl sulfone (IUPAC-Name) (981)+TX+the compound of formula VII, a compound of formula B-5.1+TX+the compound of formula VII, a compound of formula B-5.2+TX+the compound of formula VII, a compound of formula B-5.3+TX+the compound of formula VII, a compound of formula B-5.4+TX+the compound of formula VII, a compound of formula B-5.5+TX+the compound of formula VII, a compound of formula B-5.6+TX+the compound of formula VII, a compound of formula B-5.7+TX+the compound of formula VII, the compound B-5.8+TX+the compound of formula VII, the compound B-5.9+TX+the compound of formula VII, compound B-5.10+TX+the compound of formula VII, bixafen+TX+the compound of formula VII, fluopyram+TX+the compound of formula VII, the compound B-5.13+TX+the compound of formula VII, the compound B-5.14+TX+the compound of formula VII, the compound B-5.15+TX+the compound of formula VII, the compound B-5.16+TX+the compound of formula VII, the compound B-5.17+TX+the compound of formula VII, the compound B-5.18+TX+the compound of formula VII, acibenzolar-S-methyl (6)+TX+the compound of formula VII, chlormequat chloride (137)+TX+the compound of formula VII, ethephon (307)+TX+the compound of formula VII, mepiquat chloride (509)+TX+the compound of formula VII, trinexapac-ethyl (841)+TX+the compound of formula VII, abamectin (1)+TX+the compound of formula VII, clothianidin (165)+TX+the compound of formula VII, emamectin benzoate (291)+TX+the compound of formula VII, imidacloprid (458)+TX+the compound of formula VII, tefluthrin (769)+TX+the compound of formula VII, thiamethoxam (792)+TX+the compound of formula VII, glyphosate (419)+TX+the compound of formula VII, a compound of formula V

fomesafen+TX+the compound of formula VII, isopyrazam+TX+the compound of formula VII, sedaxane+TX+the compound of formula VII, the compound of formula (VI)

+TX+the compound of formula VII, 1-[4-[4-[(5S)5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl]piperidin-1-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone+TX+the compound of formula VII, 1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl]piperidin-1-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone+TX+the compound of formula VII, fluxapyroxad+TX+the compound of formula VII, phosphorous acid+TX+the compound of formula VII, phosphorous acid sodium salt+TX+the compound of formula VII and phosphorous acid ammonium salt+TX+the compound of formula VII.

The active ingredient combinations (A)+(B)+(C) can additionally contain phosphorous acid (IUPAC name phosphonic acid) and salts of phosphorous acid, particularly the sodium, potassium and ammonium salt. Phosphorous acid and salts of phosphorous acid, particularly the sodium, potassium and ammonium salt can also be mixed with components (A)+(B) and (A)+(C). The mixture of components (A)+(B)+(C) with phosphorous acid and salts of phosphorous acid, particularly the sodium, potassium and ammonium salt represents a further embodiment of the invention.

A preferred component (A) is the compound No. 1.001 (3-(difluoromethyl)-N-methoxy-1-methyl-N-[1-methyl-2-(2,4,6-trichlorophenyl)ethyl]pyrazole-4-carboxamide). Preferred pre-mixtures which comprise component (A) and component (B) ready to mix with component (C) are selected from the group consisting of

-   the compound No. 1.001+the compound of formula VII -   the compound No. 1.001+isopyrazam -   the compound No. 1.001+difenoconazole -   the compound No. 1.001+azoxystrobin -   the compound No. 1.001+prothioconazole -   the compound No. 1.001+tebuconazole -   the compound No. 1.001+pyraclostrobin -   the compound No. 1.001+trifloxystrobin -   the compound No. 1.001+fludioxonil and -   the compound No. 1.001+cyprodinil.

Preferred components (C) for the mixture with pre-mixtures of components (A) and (B) mentioned above are selected from the group consisting of the compound of formula VII, fluxapyroxad, bixafen, penthiopyrad, fluopyram, boscalid, isopyrazam, propiconazole, cyproconazole, difenoconazole, prothioconazole, thiabendazole azoxystrobin, thiophanate methyl and iminoctadine tris(albesilate), with the proviso that in each composition component (B) is different from component (C).

Especially preferred components (C) for the mixture with pre-mixtures of components (A) and (B) mentioned above are selected from the group consisting of isopyrazam, difenoconazole, azoxystrobin, prothioconazole, tebuconazole, pyraclostrobin, trifloxystrobin, fludioxonil, cyprodinil and fluazinam, with the proviso that in each composition component (B) is different from component (C).

Especially preferred embodiments of the present invention are selected from the following mixtures of active ingredients:

-   the compound No. 1.001+the compound of formula VII+isopyrazam; -   the compound No. 1.001+the compound of formula VII+difenoconazole; -   the compound No. 1.001+the compound of formula VII+azoxystrobin; -   the compound No. 1.001+the compound of formula VII+prothioconazole; -   the compound No. 1.001+the compound of formula VII+tebuconazole; -   the compound No. 1.001+the compound of formula VII+pyraclostrobin; -   the compound No. 1.001+the compound of formula VII+trifloxystrobin; -   the compound No. 1.001+the compound of formula VII+fludioxonil; -   the compound No. 1.001+the compound of formula VII+cyprodinil; -   the compound No. 1.001+the compound of formula VII+fluazinam; -   the compound No. 1.001+isopyrazam+difenoconazole; -   the compound No. 1.001+isopyrazam+azoxystrobin; -   the compound No. 1.001+isopyrazam+prothioconazole; -   the compound No. 1.001+isopyrazam+tebuconazole; -   the compound No. 1.001+isopyrazam+pyraclostrobin; -   the compound No. 1.001+isopyrazam+trifloxystrobin; -   the compound No. 1.001+isopyrazam+fludioxonil; -   the compound No. 1.001+isopyrazam+cyprodinil; -   the compound No. 1.001+isopyrazam+fluazinam; -   the compound No. 1.001+difenoconazole+azoxystrobin; -   the compound No. 1.001+difenoconazole+prothioconazole; -   the compound No. 1.001+difenoconazole+tebuconazole; -   the compound No. 1.001+difenoconazole+pyraclostrobin; -   the compound No. 1.001+difenoconazole+trifloxystrobin; -   the compound No. 1.001+difenoconazole+fludioxonil; -   the compound No. 1.001+difenoconazole+cyprodinil; -   the compound No. 1.001+difenoconazole+fluazinam; -   the compound No. 1.001+azoxystrobin+prothioconazole; -   the compound No. 1.001+azoxystrobin+tebuconazole; -   the compound No. 1.001+azoxystrobin+pyraclostrobin; -   the compound No. 1.001+azoxystrobin+trifloxystrobin; -   the compound No. 1.001+azoxystrobin+fludioxonil; -   the compound No. 1.001+azoxystrobin+cyprodinil; -   the compound No. 1.001+azoxystrobin+fluazinam; -   the compound No. 1.001+prothioconazole+tebuconazole; -   the compound No. 1.001+prothioconazole+pyraclostrobin; -   the compound No. 1.001+prothioconazole+trifloxystrobin; -   the compound No. 1.001+prothioconazole+fludioxonil; -   the compound No. 1.001+prothioconazole+cyprodinil; -   the compound No. 1.001+prothioconazole+fluazinam; -   the compound No. 1.001+tebuconazole+pyraclostrobin; -   the compound No. 1.001+tebuconazole+trifloxystrobin; -   the compound No. 1.001+tebuconazole+fludioxonil; -   the compound No. 1.001+tebuconazole+cyprodinil; -   the compound No. 1.001+tebuconazole+fluazinam; -   the compound No. 1.001+pyraclostrobin+trifloxystrobin; -   the compound No. 1.001+pyraclostrobin+fludioxonil; -   the compound No. 1.001+pyraclostrobin+cyprodinil; -   the compound No. 1.001+pyraclostrobin+fluazinam; -   the compound No. 1.001+trifloxystrobin+fludioxonil; -   the compound No. 1.001+trifloxystrobin+cyprodinil; -   the compound No. 1.001+trifloxystrobin+fluazinam; -   the compound No. 1.001+fludioxonil+cyprodinil; -   the compound No. 1.001+fludioxonil+fluazinam; and -   the compound No. 1.001+cyprodinil+fluazinam.

The active ingredient combinations are effective against harmful microorganisms, such as microorganisms, that cause phytopathogenic diseases, in particular against phytopathogenic fungi and bacteria.

The active ingredient combinations are effective especially against phytopathogenic fungi belonging to the following classes: Ascomycetes (e.g. Venturia, Podosphaera, Erysiphe, Monilinia, Mycosphaerella, Uncinula); Basidiomycetes (e.g. the genus Hemileia, Rhizoctonia, Phakopsora, Puccinia, Ustilago, Tilletia); Fungi imperfecti (also known as Deuteromycetes; e.g. Botrytis, Helminthosporium, Rhynchosporium, Fusarium, Septoria, Cercospora, Alternaria, Pyricularia and Pseudocercosporella); Oomycetes (e.g. Phytophthora, Peronospora, Pseudoperonospora, Albugo, Bremia, Pythium, Pseudosclerospora, Plasmopara).

According to the invention “useful plants” typically comprise the following species of plants: grape vines; cereals, such as wheat, barley, rye or oats; beet, such as sugar beet or fodder beet; fruits, such as pomes, stone fruits or soft fruits, for example apples, pears, plums, peaches, almonds, cherries, strawberries, raspberries or blackberries; leguminous plants, such as beans, lentils, peas or soybeans; oil plants, such as rape, mustard, poppy, olives, sunflowers, coconut, castor oil plants, cocoa beans or groundnuts; cucumber plants, such as marrows, cucumbers or melons; fibre plants, such as cotton, flax, hemp or jute; citrus fruit, such as oranges, lemons, grapefruit or mandarins; vegetables, such as spinach, lettuce, asparagus, cabbages, carrots, onions, tomatoes, potatoes, cucurbits or paprika; lauraceae, such as avocados, cinnamon or camphor; maize; tobacco; nuts; coffee; sugar cane; tea; vines; hops; durian; bananas; natural rubber plants; turf or ornamentals, such as flowers, shrubs, broad-leaved trees or evergreens, for example conifers. This list does not represent any limitation.

The term “useful plants” is to be understood as including also useful plants that have been rendered tolerant to herbicides like bromoxynil or classes of herbicides (such as, for example, HPPD inhibitors, ALS inhibitors, for example primisulfuron, prosulfuron and trifloxysulfuron, EPSPS (5-enol-pyrovyl-shikimate-3-phosphate-synthase) inhibitors, GS (glutamine synthetase) inhibitors) as a result of conventional methods of breeding or genetic engineering. An example of a crop that has been rendered tolerant to imidazolinones, e.g. imazamox, by conventional methods of breeding (mutagenesis) is Clearfield® summer rape (Canola). Examples of crops that have been rendered tolerant to herbicides or classes of herbicides by genetic engineering methods include glyphosate- and glufosinate-resistant maize varieties commercially available under the trade names RoundupReady®, Herculex I® and LibertyLink®.

The term “useful plants” is to be understood as including also useful plants which have been so transformed by the use of recombinant DNA techniques that they are capable of synthesising one or more selectively acting toxins, such as are known, for example, from toxin-producing bacteria, especially those of the genus Bacillus.

Toxins that can be expressed by such transgenic plants include, for example, insecticidal proteins, for example insecticidal proteins from Bacillus cereus or Bacillus popliae; or insecticidal proteins from Bacillus thuringiensis, such as δ-endotoxins, e.g. CryIA(b), CryIA(c), CryIF, CryIF(a2), CryIIA(b), CryIIIA, CryIIIB(b1) or Cry9c, or vegetative insecticidal proteins (VIP), e.g. VIP1, VIP2, VIP3 or VIP3A; or insecticidal proteins of bacteria colonising nematodes, for example Photorhabdus spp. or Xenorhabdus spp., such as Photorhabdus luminescens, Xenorhabdus nematophilus; toxins produced by animals, such as scorpion toxins, arachnid toxins, wasp toxins and other insect-specific neurotoxins; toxins produced by fungi, such as Streptomycetes toxins, plant lectins, such as pea lectins, barley lectins or snowdrop lectins; agglutinins; proteinase inhibitors, such as trypsine inhibitors, serine protease inhibitors, patatin, cystatin, papain inhibitors; ribosome-inactivating proteins (RIP), such as ricin, maize-RIP, abrin, luffin, saporin or bryodin; steroid metabolism enzymes, such as 3-hydroxysteroidoxidase, ecdysteroid-UDP-glycosyl-transferase, cholesterol oxidases, ecdysone inhibitors, HMG-COA-reductase, ion channel blockers, such as blockers of sodium or calcium channels, juvenile hormone esterase, diuretic hormone receptors, stilbene synthase, bibenzyl synthase, chitinases and glucanases.

In the context of the present invention there are to be understood by δ-endotoxins, for example CryIA(b), CryIA(c), CryIF, CryIF(a2), CryIIA(b), CryIIIA, CryIIIB(b1) or Cry9c, or vegetative insecticidal proteins (VIP), for example VIP1, VIP2, VIP3 or VIP3A, expressly also hybrid toxins, truncated toxins and modified toxins. Hybrid toxins are produced recombinantly by a new combination of different domains of those proteins (see, for example, WO 02/15701). An example for a truncated toxin is a truncated CryIA(b), which is expressed in the Bt11 maize from Syngenta Seed SAS, as described below. In the case of modified toxins, one or more amino acids of the naturally occurring toxin are replaced. In such amino acid replacements, preferably non-naturally present protease recognition sequences are inserted into the toxin, such as, for example, in the case of CryIIIA055, a cathepsin-D-recognition sequence is inserted into a CryIIIA toxin (see WO 03/018810)

Examples of such toxins or transgenic plants capable of synthesising such toxins are disclosed, for example, in EP-A-0 374 753, WO 93/07278, WO 95/34656, EP-A-0 427 529, EP-A-451 878 and WO 03/052073.

The processes for the preparation of such transgenic plants are generally known to the person skilled in the art and are described, for example, in the publications mentioned above. CryI-type deoxyribonucleic acids and their preparation are known, for example, from WO 95/34656, EP-A-0 367 474, EP-A-0 401 979 and WO 90/13651.

The toxin contained in the transgenic plants imparts to the plants tolerance to harmful insects. Such insects can occur in any taxonomic group of insects, but are especially commonly found in the beetles (Coleoptera), two-winged insects (Diptera) and butterflies (Lepidoptera).

Transgenic plants containing one or more genes that code for an insecticidal resistance and express one or more toxins are known and some of them are commercially available. Examples of such plants are: YieldGard® (maize variety that expresses a CryIA(b) toxin); YieldGard Rootworm® (maize variety that expresses a CryIIIB(b1) toxin); YieldGard Plus® (maize variety that expresses a CryIA(b) and a CryIIIB(b1) toxin); Starlink® (maize variety that expresses a Cry9(c) toxin); Herculex I® (maize variety that expresses a CryIF(a2) toxin and the enzyme phosphinothricine N-acetyltransferase (PAT) to achieve tolerance to the herbicide glufosinate ammonium); NuCOTN 33B® (cotton variety that expresses a CryIA(c) toxin); Bollgard I® (cotton variety that expresses a CryIA(c) toxin); Bollgard II® (cotton variety that expresses a CryIA(c) and a CryIIA(b) toxin); VIPCOT® (cotton variety that expresses a VIP toxin); NewLeaf® (potato variety that expresses a CryIIIA toxin); NatureGard® and Protecta®.

Further examples of such transgenic crops are:

-   1. Bt11 Maize from Syngenta Seeds SAS, Chemin de l'Hobit 27, F-31     790 St. Sauveur, France, registration number C/FR/96/05/10.     Genetically modified Zea mays which has been rendered resistant to     attack by the European corn borer (Ostrinia nubilalis and Sesamia     nonagrioides) by transgenic expression of a truncated CryIA(b)     toxin. Bt11 maize also transgenically expresses the enzyme PAT to     achieve tolerance to the herbicide glufosinate ammonium. -   2. Bt176 Maize from Syngenta Seeds SAS, Chemin de l'Hobit 27, F-31     790 St. Sauveur, France, registration number C/FR/96/05/10.     Genetically modified Zea mays which has been rendered resistant to     attack by the European corn borer (Ostrinia nubilalis and Sesamia     nonagrioides) by transgenic expression of a CryIA(b) toxin. Bt176     maize also transgenically expresses the enzyme PAT to achieve     tolerance to the herbicide glufosinate ammonium. -   3. MIR604 Maize from Syngenta Seeds SAS, Chemin de l'Hobit 27, F-31     790 St. Sauveur, France, registration number C/FR/96/05/10. Maize     which has been rendered insect-resistant by transgenic expression of     a modified CryIIIA toxin. This toxin is Cry3A055 modified by     insertion of a cathepsin-D-protease recognition sequence. The     preparation of such transgenic maize plants is described in WO     03/018810. -   4. MON 863 Maize from Monsanto Europe S.A. 270-272 Avenue de     Tervuren, B-1150 Brussels, Belgium, registration number C/DE/02/9.     MON 863 expresses a CryIIIB(b1) toxin and has resistance to certain     Coleoptera insects. -   5. IPC 531 Cotton from Monsanto Europe S.A. 270-272 Avenue de     Tervuren, B-1150 Brussels, Belgium, registration number C/ES/96/02. -   6. 1507 Maize from Pioneer Overseas Corporation, Avenue Tedesco, 7     B-1160 Brussels, Belgium, registration number C/NL/00/10.     Genetically modified maize for the expression of the protein Cry1F     for achieving resistance to certain Lepidoptera insects and of the     PAT protein for achieving tolerance to the herbicide glufosinate     ammonium. -   7. NK603×MON 810 Maize from Monsanto Europe S.A. 270-272 Avenue de     Tervuren, B-1150 Brussels, Belgium, registration number     C/GB/02/M3/03. Consists of conventionally bred hybrid maize     varieties by crossing the genetically modified varieties NK603 and     MON 810. NK603×MON 810 Maize transgenically expresses the protein     CP4 EPSPS, obtained from Agrobacterium sp. strain CP4, which imparts     tolerance to the herbicide Roundup® (contains glyphosate), and also     a CryIA(b) toxin obtained from Bacillus thuringiensis subsp.     kurstaki which brings about tolerance to certain Lepidoptera,     include the European corn borer.

Transgenic crops of insect-resistant plants are also described in BATS (Zentrum für Biosicherheit and Nachhaltigkeit, Zentrum BATS, Clarastrasse 13, 4058 Basel, Switzerland) Report 2003, (http://bats.ch).

The term “useful plants” is to be understood as including also useful plants which have been so transformed by the use of recombinant DNA techniques that they are capable of synthesising antipathogenic substances having a selective action, such as, for example, the so-called “pathogenesis-related proteins” (PRPs, see e.g. EP-A-0 392 225). Examples of such antipathogenic substances and transgenic plants capable of synthesising such antipathogenic substances are known, for example, from EP-A-0 392 225, WO 95/33818, and EP-A-0 353 191. The methods of producing such transgenic plants are generally known to the person skilled in the art and are described, for example, in the publications mentioned above.

Antipathogenic substances which can be expressed by such transgenic plants include, for example, ion channel blockers, such as blockers for sodium and calcium channels, for example the viral KP1, KP4 or KP6 toxins; stilbene synthases; bibenzyl synthases; chitinases; glucanases; the so-called “pathogenesis-related proteins” (PRPs; see e.g. EP-A-0 392 225); antipathogenic substances produced by microorganisms, for example peptide antibiotics or heterocyclic antibiotics (see e.g. WO 95/33818) or protein or polypeptide factors involved in plant pathogen defence (so-called “plant disease resistance genes”, as described in WO 03/000906).

Useful plants of elevated interest in connection with present invention are cereals; soybean; rice; oil seed rape; pome fruits; stone fruits; peanuts; coffee; tea; strawberries; turf; vines and vegetables, such as tomatoes, potatoes, cucurbits and lettuce.

The term “locus” of a useful plant as used herein is intended to embrace the place on which the useful plants are growing, where the plant propagation materials of the useful plants are sown or where the plant propagation materials of the useful plants will be placed into the soil. An example for such a locus is a field, on which crop plants are growing.

The term “plant propagation material” is understood to denote generative parts of a plant, such as seeds, which can be used for the multiplication of the latter, and vegetative material, such as cuttings or tubers, for example potatoes. There may be mentioned for example seeds (in the strict sense), roots, fruits, tubers, bulbs, rhizomes and parts of plants. Germinated plants and young plants which are to be transplanted after germination or after emergence from the soil, may also be mentioned. These young plants may be protected before transplantation by a total or partial treatment by immersion. Preferably “plant propagation material” is understood to denote seeds.

A further aspect of the instant invention is a method of protecting natural substances of plant and/or animal origin, which have been taken from the natural life cycle, and/or their processed forms against attack of fungi, which comprises applying to said natural substances of plant and/or animal origin or their processed forms a combination of components (A) and (B) and (C) in a synergistically effective amount.

According to the instant invention, the term “natural substances of plant origin, which have been taken from the natural life cycle” denotes plants or parts thereof which have been harvested from the natural life cycle and which are in the freshly harvested form. Examples of such natural substances of plant origin are stalks, leafs, tubers, seeds, fruits or grains. According to the instant invention, the term “processed form of a natural substance of plant origin” is understood to denote a form of a natural substance of plant origin that is the result of a modification process. Such modification processes can be used to transform the natural substance of plant origin in a more storable form of such a substance (a storage good). Examples of such modification processes are pre-drying, moistening, crushing, comminuting, grounding, compressing or roasting. Also falling under the definition of a processed form of a natural substance of plant origin is timber, whether in the form of crude timber, such as construction timber, electricity pylons and barriers, or in the form of finished articles, such as furniture or objects made from wood.

According to the instant invention, the term “natural substances of animal origin, which have been taken from the natural life cycle and/or their processed forms” is understood to denote material of animal origin such as skin, hides, leather, furs, hairs and the like.

The combinations according the present invention can prevent disadvantageous effects such as decay, discoloration or mold.

A preferred embodiment is a method of protecting natural substances of plant origin, which have been taken from the natural life cycle, and/or their processed forms against attack of fungi, which comprises applying to said natural substances of plant and/or animal origin or their processed forms a combination of components (A) and (B) and (C) in a synergistically effective amount.

A further preferred embodiment is a method of protecting fruits, preferably pomes, stone fruits, soft fruits and citrus fruits, which have been taken from the natural life cycle, and/or their processed forms, which comprises applying to said fruits and/or their processed forms a combination of components (A) and (B) and (C) in a synergistically effective amount.

The combinations of the present invention may also be used in the field of protecting industrial material against attack of fungi. According to the instant invention, the term “industrial material” denotes non-live material which have been prepared for use in industry. For example, industrial materials which are intended to be protected against attack of fungi can be glues, sizes, paper, board, textiles, carpets, leather, wood, constructions, paints, plastic articles, cooling lubricants, aqueous hydraulic fluids and other materials which can be infested with, or decomposed by, microorganisms. Cooling and heating systems, ventilation and air conditioning systems and parts of production plants, for example cooling-water circuits, which may be impaired by multiplication of microorganisms may also be mentioned from amongst the materials to be protected. The combinations according the present invention can prevent disadvantageous effects such as decay, discoloration or mold.

The combinations of the present invention may also be used in the field of protecting technical material against attack of fungi. According to the instant invention, the term “technical material” includes paper; carpets; constructions; cooling and heating systems; ventilation and air conditioning systems and the like. The combinations according the present invention can prevent disadvantageous effects such as decay, discoloration or mold.

The combinations according to the present invention are particularly effective against powdery mildews; rusts; leafspot species; early blights and molds; especially against Septoria, Puccinia, Erysiphe, Pyrenophora and Tapesia in cereals; Phakopsora in soybeans; Hemileia in coffee; Phragmidium in roses; Alternaria in potatoes, tomatoes and cucurbits; Sclerotinia in turf, vegetables, sunflower and oil seed rape; black rot, red fire, powdery mildew, grey mold and dead arm disease in vine; Botrytis cinerea in fruits; Monilinia spp. in fruits and Penicillium spp. in fruits.

The combinations according to the present invention are furthermore particularly effective against seedborne and soilborne diseases, such as Alternaria spp., Ascochyta spp., Botrytis cinerea, Cercospora spp., Claviceps purpurea, Cochliobolus sativus, Colletotrichum spp., Epicoccum spp., Fusarium graminearum, Fusarium moniliforme, Fusarium oxysporum, Fusarium proliferatum, Fusarium solani, Fusarium subglutinans, Gäumannomyces graminis, Helminthosporium spp., Microdochium nivale, Phoma spp., Pyrenophora graminea, Pyricularia oryzae, Rhizoctonia solani, Rhizoctonia cerealis, Sclerotinia spp., Septoria spp., Sphacelotheca reilliana, Tilletia spp., Typhula incarnata, Urocystis occulta, Ustilago spp. or Verticillium spp.; in particular against pathogens of cereals, such as wheat, barley, rye or oats; maize; rice; cotton; soybean; turf; sugarbeet; oil seed rape; potatoes; pulse crops, such as peas, lentils or chickpea; and sunflower.

The combinations according to the present invention are furthermore particularly effective against post harvest diseases such as Botrytis cinerea, Colletotrichum musae, Curvularia lunata, Fusarium semitecum, Geotrichum candidum, Monilinia fructicola, Monilinia fructigena, Monilinia laxa, Mucor piriformis, Penicilium italicum, Penicilium solitum, Penicillium digitatum or Penicillium expansum in particular against pathogens of fruits, such as pomefruits, for example apples and pears, stone fruits, for example peaches and plums, citrus, melons, papaya, kiwi, mango, berries, for example strawberries, avocados, pomegranates and bananas, and nuts.

The amount of a combination of the invention to be applied, will depend on various factors, such as the compounds employed; the subject of the treatment, such as, for example plants, soil or seeds; the type of treatment, such as, for example spraying, dusting or seed dressing; the purpose of the treatment, such as, for example prophylactic or therapeutic; the type of fungi to be controlled or the application time.

It has been found that the use of components (B) and (C) in combination with the compound of formula I surprisingly and substantially enhance the effectiveness of the latter against fungi, and vice versa. Additionally, the method of the invention is effective against a wider spectrum of such fungi that can be combated with the active ingredients of this method, when used solely.

The active ingredient mixture of the compounds of formula I selected from table 1 and 2 with active ingredients (B+C) described above comprises a compound selected from table 1 and 2 and an active ingredient as described above preferably in a mixing ratio of from 1000:1 to 1:1000, especially from 50:1 to 1:50, more especially in a ratio of from 20:1 to 1:20, even more especially from 10:1 to 1:10, very especially from 5:1 and 1:5, special preference being given to a ratio of from 2:1 to 1:2, and a ratio of from 4:1 to 2:1 being likewise preferred, above all in a ratio of 1:1, or 5:1, or 5:2, or 5:3, or 5:4, or 4:1, or 4:2, or 4:3, or 3:1, or 3:2, or 2:1, or 1:5, or 2:5, or 3:5, or 4:5, or 1:4, or 2:4, or 3:4, or 1:3, or 2:3, or 1:2, or 1:600, or 1:300, or 1:150, or 1:35, or 2:35, or 4:35, or 1:75, or 2:75, or 4:75, or 1:6000, or 1:3000, or 1:1500, or 1:350, or 2:350, or 4:350, or 1:750, or 2:750, or 4:750. Those mixing ratios are understood to include, on the one hand, ratios by weight and also, on other hand, molar ratios.

In a preferred embodiment of the invention, the ratios by weight of component (A) selected from table 1 and 2 to the mixture of components (B) and (C) are 4:1 to 1:4.

In a preferred embodiment of the invention, ratios by weight of component (B) to component (C) are from 2:1 to 1:6.

The mixtures comprising a compound of formula I selected from table 1 and 2 and one or more active ingredients as described above can be applied, for example, in a single “ready-mix” form, in a combined spray mixture composed from separate formulations of the single active ingredient components, such as a “tank-mix”, and in a combined use of the single active ingredients when applied in a sequential manner, i.e. one after the other with a reasonably short period, such as a few hours or days. The order of applying the compounds of formula I selected from table 1 and the active ingredients as described above is not essential for working the present invention.

The synergistic activity of the combination is apparent from the fact that the fungicidal activity of the composition of (A)+(B)+(C) is greater than the sum of the fungicidal activities of (the mixture of A+B) and (C), or (the mixture of A+C) and (B) or (A) and (B) and (C).

The method of the invention comprises applying to the useful plants, the locus thereof or propagation material thereof in admixture or separately, a synergistically effective aggregate amount of a component (A) and a component (B) and a component (C).

Some of said combinations according to the invention have a systemic action and can be used as foliar, soil and seed treatment fungicides.

With the combinations according to the invention it is possible to inhibit or destroy the phytopathogenic microorganisms which occur in plants or in parts of plants (fruit, blossoms, leaves, stems, tubers, roots) in different useful plants, while at the same time the parts of plants which grow later are also protected from attack by phytopathogenic microorganisms.

The combinations of the present invention are of particular interest for controlling a large number of fungi in various useful plants or their seeds, especially in field crops such as potatoes, tobacco and sugarbeets, and wheat, rye, barley, oats, rice, maize, lawns, cotton, soybeans, oil seed rape, pulse crops, sunflower, coffee, sugarcane, fruit and ornamentals in horticulture and viticulture, in vegetables such as cucumbers, beans and cucurbits.

The combinations according to the invention are applied by treating the fungi, the useful plants, the locus thereof, the propagation material thereof, the natural substances of plant and/or animal origin, which have been taken from the natural life cycle, and/or their processed forms, or the industrial materials threatened by fungus attack with a combination of components (A) and (B) and (C), preferably in a synergistically effective amount.

The combinations according to the invention may be applied before or after infection of the useful plants, the propagation material thereof, the natural substances of plant and/or animal origin, which have been taken from the natural life cycle, and/or their processed forms, or the industrial materials by the fungi.

The combinations according to the invention are particularly useful for controlling the following plant diseases:

-   Alternaria species in fruit and vegetables, -   Ascochyta species in pulse crops, -   Botrytis cinerea in strawberries, tomatoes, sunflower, pulse crops,     vegetables and grapes, -   Cercospora arachidicola in peanuts, -   Cochliobolus sativus in cereals, -   Colletotrichum species in pulse crops, -   Erysiphe species in cereals, -   Erysiphe cichoracearum and Sphaerotheca fuliginea in cucurbits, -   Fusarium species in cereals and maize, -   Gäumannomyces graminis in cereals and lawns, -   Helminthosporium species in maize, rice and potatoes, -   Hemileia vastatrix on coffee, -   Microdochium species in wheat and rye, -   Phakopsora species in soybean, -   Puccinia species in cereals, broadleaf crops and perrenial plants, -   Pseudocercosporella species in cereals, -   Phragmidium mucronatum in roses, -   Podosphaera species in fruits, -   Pyrenophora species in barley, -   Pyricularia oryzae in rice, -   Ramularia collo-cygni in barley, -   Rhizoctonia species in cotton, soybean, cereals, maize, potatoes,     rice and lawns, -   Rhynchosporium secalis in barley and rye, -   Sclerotinia species in lawns, lettuce, vegetables and oil seed rape, -   Septoria species in cereals, soybean and vegetables, -   Sphacelotheca reilliana in maize, -   Tilletia species in cereals, -   Uncinula necator, Guignardia bidwellii and Phomopsis viticola in     vines, -   Urocystis occulta in rye, -   Ustilago species in cereals and maize, -   Venturia species in fruits, -   Monilinia species on fruits, -   Penicillium species on citrus and apples.

The combinations according to the invention are preventively and/or curatively valuable active ingredients in the field of pest control, even at low rates of application, which have a very favorable biocidal spectrum and are well tolerated by warm-blooded species, fish and plants.

The active ingredients according to the invention which are partially known for their insecticidal action act against all or individual developmental stages of normally sensitive, but also resistant, animal pests, such as insects or representatives of the order Acarina. The insecticidal or acaricidal activity of the combinations according to the invention can manifest itself directly, i.e. in destruction of the pests, which takes place either immediately or only after some time has elapsed, for example during ecdysis, or indirectly, for example in a reduced oviposition and/or hatching rate, a good activity corresponding to a destruction rate (mortality) of at least 50 to 60%.

Examples of the abovementioned animal pests are:

from the order Acarina, for example,

-   Acarus siro, Aceria sheldoni, Aculus schlechtendali, Amblyomma spp.,     Argas spp., Boophilus spp., Brevipalpus spp., Bryobia praetiosa,     Calipitrimerus spp., Chorioptes spp., Dermanyssus gallinae,     Eotetranychus carpini, Eriophyes spp., Hyalomma spp., Ixodes spp.,     Olygonychus pratensis, Ornithodoros spp., Panonychus spp.,     Phyllocoptruta oleivora, Polyphagotarsonemus latus, Psoroptes spp.,     Rhipicephalus spp., Rhizoglyphus spp., Sarcoptes spp., Tarsonemus     spp. and Tetranychus spp.;     from the order Anoplura, for example, -   Haematopinus spp., Linognathus spp., Pediculus spp., Pemphigus spp.     and Phylloxera spp.;     from the order Coleoptera, for example, -   Agriotes spp., Anthonomus spp., Atomaria linearis, Chaetocnema     tibialis, Cosmopolites spp., Curculio spp., Dermestes spp.,     Diabrotica spp., Epilachna spp., Eremnus spp., Leptinotarsa     decemlineata, Lissorhoptrus spp., Melolontha spp., Orycaephilus     spp., Otiorhynchus spp., Phlyctinus spp., Popillia spp., Psylliodes     spp., Rhizopertha spp., Scarabeidae, Sitophilus spp., Sitotroga     spp., Tenebrio spp., Tribolium spp. and Trogoderma spp.;     from the order Diptera, for example, -   Aedes spp., Antherigona soccata, Bibio hortulanus, Calliphora     erythrocephala, Ceratitis spp., Chrysomyia spp., Culex spp.,     Cuterebra spp., Dacus spp., Drosophila melanogaster, Fannia spp.,     Gastrophilus spp., Glossina spp., Hypoderma spp., Hyppobosca spp.,     Liriomyza spp., Lucilia spp., Melanagromyza spp., Musca spp.,     Oestrus spp., Orseolia spp., Oscinella frit, Pegomyia hyoscyami,     Phorbia spp., Rhagoletis pomonella, Sciara spp., Stomoxys spp.,     Tabanus spp., Tannia spp. and Tipula spp.;     from the order Heteroptera, for example, -   Cimex spp., Distantiella theobroma, Dysdercus spp., Euchistus spp.,     Eurygaster spp., Leptocorisa spp., Nezara spp., Piesma spp.,     Rhodnius spp., Sahlbergella singularis, Scotinophara spp. and     Triatoma spp.;     from the order Homoptera, for example, -   Aleurothrixus floccosus, Aleyrodes brassicae, Aonidiella spp.,     Aphididae, Aphis spp., Aspidiotus spp., Bemisia tabaci, Ceroplaster     spp., Chrysomphalus aonidium, Chrysomphalus dictyospermi, Coccus     hesperidum, Empoasca spp., Eriosoma larigerum, Erythroneura spp.,     Gascardia spp., Laodelphax spp., Lecanium corni, Lepidosaphes spp.,     Macrosiphus spp., Myzus spp., Nephotettix spp., Nilaparvata spp.,     Parlatoria spp., Pemphigus spp., Planococcus spp., Pseudaulacaspis     spp., Pseudococcus spp., Psylla spp., Pulvinaria aethiopica,     Quadraspidiotus spp., Rhopalosiphum spp., Saissetia spp.,     Scaphoideus spp., Schizaphis spp., Sitobion spp., Trialeurodes     vaporariorum, Trioza erytreae and Unaspis citri;     from the order Hymenoptera, for example, -   Acromyrmex, Atta spp., Cephus spp., Diprion spp., Diprionidae,     Gilpinia polytoma, Hoplocampa spp., Lasius spp., Monomorium     pharaonis, Neodiprion spp., Solenopsis spp. and Vespa spp.;     from the order Isoptera, for example, -   Reticulitermes spp.;     from the order Lepidoptera, for example, -   Acleris spp., Adoxophyes spp., Aegeria spp., Agrotis spp., Alabama     argillaceae, Amylois spp., Anticarsia gemmatalis, Archips spp.,     Argyrotaenia spp., Autographa spp., Busseola fusca, Cadra cautella,     Carposina nipponensis, Chilo spp., Choristoneura spp., Clysia     ambiguella, Cnaphalocrocis spp., Cnephasia spp., Cochylis spp.,     Coleophora spp., Crocidolomia binotalis, Cryptophlebia leucotreta,     Cydia spp., Diatraea spp., Diparopsis castanea, Earias spp.,     Ephestia spp., Eucosma spp., Eupoecilia ambiguella, Euproctis spp.,     Euxoa spp., Grapholita spp., Hedya nubiferana, Heliothis spp.,     Hellula undalis, Hyphantria cunea, Keiferia lycopersicella,     Leucoptera scitella, Lithocollethis spp., Lobesia botrana, Lymantria     spp., Lyonetia spp., Malacosoma spp., Mamestra brassicae, Manduca     sexta, Operophtera spp., Ostrinia nubilalis, Pammene spp., Pandemis     spp., Panolis flammea, Pectinophora gossypiela, Phthorimaea     operculella, Pieris rapae, Pieris spp., Plutella xylostella, Prays     spp., Scirpophaga spp., Sesamia spp., Sparganothis spp., Spodoptera     spp., Synanthedon spp., Thaumetopoea spp., Tortrix spp.,     Trichoplusia ni and Yponomeuta spp.;     from the order Mallophaga, for example, -   Damalinea spp. and Trichodectes spp.;     from the order Orthoptera, for example, -   Blatta spp., Blattella spp., Gryllotalpa spp., Leucophaea maderae,     Locusta spp., Periplaneta spp. and Schistocerca spp.;     from the order Psocoptera, for example, -   Liposcelis spp.;     from the order Siphonaptera, for example, -   Ceratophyllus spp., Ctenocephalides spp. and Xenopsylla cheopis;     from the order Thysanoptera, for example, -   Frankliniella spp., Hercinothrips spp., Scirtothrips aurantii,     Taeniothrips spp., Thrips palmi and Thrips tabaci;     from the order Thysanura, for example, -   Lepisma saccharina; -   nematodes, for example root knot nematodes, stem eelworms and foliar     nematodes; -   especially Heterodera spp., for example Heterodera schachtii,     Heterodora avenae and Heterodora trifolii; Globodera spp., for     example Globodera rostochiensis; Meloidogyne spp., for example     Meloidogyne incoginita and Meloidogyne javanica; Radopholus spp.,     for example Radopholus similis; Pratylenchus, for example     Pratylenchus neglectans and Pratylenchus penetrans; Tylenchulus, for     example Tylenchulus semipenetrans; Longidorus, Trichodorus,     Xiphinema, Ditylenchus, Aphelenchoides and Anguina; -   crucifer flea beetles (Phyllotreta spp.); -   root maggots (Delia spp.) and -   cabbage seedpod weevil (Ceutorhynchus spp.).

The combinations according to the invention can be used for controlling, i. e. containing or destroying, animal pests of the abovementioned type which occur on useful plants in agriculture, in horticulture and in forests, or on organs of useful plants, such as fruits, flowers, foliage, stalks, tubers or roots, and in some cases even on organs of useful plants which are formed at a later point in time remain protected against these animal pests.

When applied to the useful plants the compound of formula I is applied at a rate of 5 to 2000 g a.i./ha, particularly 10 to 1000 g a.i./ha, e.g. 50, 75, 100 or 200 g a.i./ha, in association with 1 to 5000 g a.i./ha, particularly 2 to 2000 g a.i./ha, e.g. 100, 250, 500, 800, 1000, 1500 g a.i./ha of component (B) and (C), depending on the class of chemical employed as component (B) and (C).

In agricultural practice the application rates of the combination according to the invention depend on the type of effect desired, and typically range from 20 to 4000 g of total combination per hectare.

When the combinations of the present invention are used for treating seed, rates of 0.001 to 50 g of a compound of formula I per kg of seed, preferably from 0.01 to 10 g per kg of seed, and 0.001 to 50 g of a compound of component (B), per kg of seed, preferably from 0.01 to 10 g per kg of seed, are generally sufficient.

The invention also provides fungicidal compositions comprising a combination of components (A) and (B) and (C) as mentioned above in a synergistically effective amount, together with an agriculturally acceptable carrier, and optionally a surfactant. In said compositions, the weight ratio of (A) to (B+C) is preferably between 1000:1 and 1:1000. In a preferred embodiment of the invention, the ratios by weight in said compositions of component (A) to the mixture of components (B) and (C) are 4:1 to 1:4. In a preferred embodiment of the invention, ratios by weight of component (B) to component (C) in said compositions are from 2:1 to 1:6.

The compositions of the invention may be employed in any conventional form, for example in the form of a twin pack, a powder for dry seed treatment (DS), an emulsion for seed treatment (ES), a flowable concentrate for seed treatment (FS), a solution for seed treatment (LS), a water dispersible powder for seed treatment (WS), a capsule suspension for seed treatment (CF), a gel for seed treatment (GF), an emulsion concentrate (EC), a suspension concentrate (SC), a suspo-emulsion (SE), a capsule suspension (CS), a water dispersible granule (WG), an emulsifiable granule (EG), an emulsion, water in oil (EO), an emulsion, oil in water (EW), a micro-emulsion (ME), an oil dispersion (OD), an oil miscible flowable (OF), an oil miscible liquid (OL), a soluble concentrate (SL), an ultra-low volume suspension (SU), an ultra-low volume liquid (UL), a technical concentrate (TK), a dispersible concentrate (DC), a wettable powder (WP) or any technically feasible formulation in combination with agriculturally acceptable adjuvants.

Such compositions may be produced in conventional manner, e.g. by mixing the active ingredients with appropriate formulation inerts (diluents, solvents, fillers and optionally other formulating ingredients such as surfactants, biocides, anti-freeze, stickers, thickeners and compounds that provide adjuvancy effects). Also conventional slow release formulations may be employed where long lasting efficacy is intended. Particularly formulations to be applied in spraying forms, such as water dispersible concentrates (e.g. EC, SC, DC, OD, SE, EW, EO and the like), wettable powders and granules, may contain surfactants such as wetting and dispersing agents and other compounds that provide adjuvancy effects, e.g. the condensation product of formaldehyde with naphthalene sulphonate, an alkylarylsulphonate, a lignin sulphonate, a fatty alkyl sulphate, and ethoxylated alkylphenol and an ethoxylated fatty alcohol.

A seed dressing formulation is applied in a manner known per se to the seeds employing the combination of the invention and a diluent in suitable seed dressing formulation form, e.g. as an aqueous suspension or in a dry powder form having good adherence to the seeds. Such seed dressing formulations are known in the art. Seed dressing formulations may contain the single active ingredients or the combination of active ingredients in encapsulated form, e.g. as slow release capsules or microcapsules.

In general, the formulations include from 0.01 to 90% by weight of active agent, from 0 to 20% agriculturally acceptable surfactant and 10 to 99.99% solid or liquid formulation inerts and adjuvant(s), the active agent consisting of at least the compound of formula I together with component (B) and (C), and optionally other active agents, particularly microbiocides or conservatives or the like. Concentrated forms of compositions generally contain in between about 2 and 80%, preferably between about 5 and 70% by weight of active agent. Application forms of formulation may for example contain from 0.01 to 20% by weight, preferably from 0.01 to 5% by weight of active agent. Whereas commercial products will preferably be formulated as concentrates, the end user will normally employ diluted formulations.

The Examples which follow serve to illustrate the invention, “active ingredient” denoting a mixture of compound I and compounds of component (B+C) in a specific mixing ratio.

FORMULATION EXAMPLES

Wettable powders a) b) c) active ingredient [I:comp (B + C) = 1:3(a), 1:2(b), 25%  50% 75% 1:1(c)] sodium lignosulfonate 5% 5% — sodium lauryl sulfate 3% —  5% sodium diisobutylnaphthalenesulfonate — 6% 10% phenol polyethylene glycol ether — 2% — (7-8 mol of ethylene oxide) highly dispersed silicic acid 5% 10% 10% Kaolin 62%  27% —

The active ingredient is thoroughly mixed with the adjuvants and the mixture is thoroughly ground in a suitable mill, affording wettable powders that can be diluted with water to give suspensions of the desired concentration.

Powders for dry seed treatment a) b) c) active ingredient [I:comp (B) = 1:3(a), 1:2(b), 25% 50% 75% 1:1(c)] light mineral oil 5% 5% 5% highly dispersed silicic acid 5% 5% — Kaolin 65% 40% — Talcum — 20

The active ingredient is thoroughly mixed with the adjuvants and the mixture is thoroughly ground in a suitable mill, affording powders that can be used directly for seed treatment.

Emulsifiable Concentrate

active ingredient (I:comp (B + C) = 1:6) 10% octylphenol polyethylene glycol ether 3% (4-5 mol of ethylene oxide) calcium dodecylbenzenesulfonate 3% castor oil polyglycol ether (35 mol of ethylene oxide) 4% Cyclohexanone 30% xylene mixture 50%

Emulsions of any required dilution, which can be used in plant protection, can be obtained from this concentrate by dilution with water.

Dusts a) b) c) Active ingredient [I:comp (B + C) = 1:6(a), 1:2(b),  5%  6%  4% 1:10(c)] talcum 95% — — Kaolin — 94% — mineral filler — — 96%

Ready-for-use dusts are obtained by mixing the active ingredient with the carrier and grinding the mixture in a suitable mill. Such powders can also be used for dry dressings for seed.

Extruder Granules

Active ingredient (I:comp (B + C) = 2:1) 15% sodium lignosulfonate 2% carboxymethylcellulose 1% Kaolin 82%

The active ingredient is mixed and ground with the adjuvants, and the mixture is moistened with water. The mixture is extruded and then dried in a stream of air.

Coated Granules

Active ingredient (I:comp (B + C) = 1:10) 8% polyethylene glycol (mol. wt. 200) 3% Kaolin 89%

The finely ground active ingredient is uniformly applied, in a mixer, to the kaolin moistened with polyethylene glycol. Non-dusty coated granules are obtained in this manner.

Suspension Concentrate

active ingredient (I:comp (B + C) = 1:8) 40% propylene glycol 10% nonylphenol polyethylene glycol ether (15 mol of ethylene oxide) 6% Sodium lignosulfonate 10% carboxymethylcellulose 1% silicone oil (in the form of a 75% emulsion in water) 1% Water 32%

The finely ground active ingredient is intimately mixed with the adjuvants, giving a suspension concentrate from which suspensions of any desired dilution can be obtained by dilution with water. Using such dilutions, living plants as well as plant propagation material can be treated and protected against infestation by microorganisms, by spraying, pouring or immersion.

Flowable Concentrate for Seed Treatment

active ingredient (I:comp (B + C) = 1:8) 40%  propylene glycol 5% copolymer butanol PO/EO 2% tristyrenephenole with 10-20 moles EO 2% 1,2-benzisothiazolin-3-one (in the form of a 20% solution in 0.5%   water) monoazo-pigment calcium salt 5% Silicone oil (in the form of a 75% emulsion in water) 0.2%   Water 45.3%  

The finely ground active ingredient is intimately mixed with the adjuvants, giving a suspension concentrate from which suspensions of any desired dilution can be obtained by dilution with water. Using such dilutions, living plants as well as plant propagation material can be treated and protected against infestation by microorganisms, by spraying, pouring or immersion.

Slow Release Capsule Suspension

28 parts of a combination of the compound of formula I and a compound of components (B+C), or of each of these compounds separately, are mixed with 2 parts of an aromatic solvent and 7 parts of toluene diisocyanate/polymethylene-polyphenylisocyanate-mixture (8:1). This mixture is emulsified in a mixture of 1.2 parts of polyvinylalcohol, 0.05 parts of a defoamer and 51.6 parts of water until the desired particle size is achieved. To this emulsion a mixture of 2.8 parts 1,6-diaminohexane in 5.3 parts of water is added. The mixture is agitated until the polymerization reaction is completed.

The obtained capsule suspension is stabilized by adding 0.25 parts of a thickener and 3 parts of a dispersing agent. The capsule suspension formulation contains 28% of the active ingredients.

The medium capsule diameter is 8-15 microns.

The resulting formulation is applied to seeds as an aqueous suspension in an apparatus suitable for that purpose.

Biological Examples

Liquid Culture Tests in Well Plates:

Mycelia fragments or conidia suspensions of a fungus, prepared either freshly from liquid cultures of the fungus or from cryogenic storage, were directly mixed into nutrient broth. DMSO solutions of the test compound (max. 10 mg/ml) was diluted with 0.025% Tween20 by factor 50 and 10 μl of this solution was pipetted into a microtiter plate (96-well format). The nutrient broth containing the fungal spores/mycelia fragments was then added to give an end concentration of the tested compound. The test plates were incubated in the dark at 24° C. and 96% rh. The inhibition of fungal growth was determined photometrically and visually after 2-4 days, depending on the pathosystem, and percent antifungal activity relative to the untreated check was calculated.

Alternaria solani/Liquid Culture:

Conidia of the fungus from cryogenic storage were directly mixed into nutrient broth (PDB potato dextrose broth). After placing a (DMSO) solution of test compound into a microtiter plate (96-well format), the nutrient broth containing the fungal spores was added. The test plates were incubated at 24° C. and the inhibition of growth was determined photometrically and visually 2-3 day after application.

Botrvotinia fuckeliana (Botrytis cinerea)/Liquid Culture:

Conidia of the fungus from cryogenic storage were directly mixed into nutrient broth (Vogels broth). After placing a (DMSO) solution of test compound into a microtiter plate (96-well format), the nutrient broth containing the fungal spores was added. The test plates were incubated at 24° C. and the inhibition of growth was determined photometrically and visually 3 days after application.

Fusarium culmorum/Liquid Culture:

Conidia of the fungus from cryogenic storage were directly mixed into nutrient broth (PDB potato dextrose broth). After placing a (DMSO) solution of test compound into a microtiter plate (96-well format), the nutrient broth containing the fungal spores was added. The test plates were incubated at 24° C. and the inhibition of growth was determined photometrically and visually 3 days after application.

Gaeumannomyces graminis/Liquid Culture:

Mycelial fragments of the fungus from cryogenic storage were directly mixed into nutrient broth (PDB potato dextrose broth). After placing a (DMSO) solution of test compound into a microtiter plate (96-well format), the nutrient broth containing the fungal spores was added. The test plates were incubated at 24° C. and the inhibition of growth was determined photometrically and visually 3-4 days after application.

Monographella nivalis (Microdochium nivale)/Liquid Culture:

Conidia of the fungus from cryogenic storage were directly mixed into nutrient broth (PDB potato dextrose broth). After placing a (DMSO) solution of test compound into a microtiter plate (96-well format), the nutrient broth containing the fungal spores was added. The test plates were incubated at 24° C. and the inhibition of growth was determined photometrically and visually 3-4 days after application.

Mycosphaerella graminicola (Septoria tritici)/Liquid Culture:

Conidia of the fungus from cryogenic storage were directly mixed into nutrient broth (PDB potato dextrose broth). After placing a (DMSO) solution of test compound into a microtiter plate (96-well format), the nutrient broth containing the fungal spores was added. The test plates were incubated at 24° C. and the inhibition of growth was determined photometrically and visually 4 days after application.

Thanatephorus cucumeris (Rhizoctonia solani)/Liquid Culture:

Mycelia fragments of a newly grown liquid culture of the fungus were directly mixed into nutrient broth (PDB potato dextrose broth). After placing a (DMSO) solution of the test compounds into a microtiter plate (96-well format), the nutrient broth containing the fungal material was added. The test plates were incubated at 24° C. and the inhibition of growth was determined photometrically and visually 3-4 days after application.

The results are shown in the following tables.

TABLE B1 The abbreviations are defined as follows: 1.001 = compound No. 1.001 STL = compound of formula VII IZM = isopyrazam Solution of STL + exp. Solution of 1.001 IZM (1:2) observed action ppm ppm ppm % activity (colby) B1.1: Gaeumannomyces graminis: 0.2000 7 0.0165 0.0335 73 0.2000 0.0165 0.0335 100 75 B1.2: Alternaria solani: 0.0008 4 0.0016 32 0.0016 32 0.0031 64 0.0001 0.0003 0 0.0003 0.0005 0 0.0005 0.0010 0 0.0010 0.0021 0 0.0021 0.0042 0 0.0041 0.0084 22 0.0008 0.0001 0.0003 20 4 0.0008 0.0010 0.0021 49 4 0.0016 0.0001 0.0003 44 32 0.0016 0.0003 0.0005 46 32 0.0016 0.0005 0.0010 61 32 0.0016 0.0010 0.0021 49 32 0.0016 0.0021 0.0042 72 32 0.0031 0.0005 0.0010 71 64 0.0031 0.0010 0.0021 75 64 0.0031 0.0021 0.0042 78 64 0.0031 0.0041 0.0084 87 72 B1.3: Monographella nivalis: 0.0125 0 0.0250 5 0.0500 45 0.2000 78 0.0083 0.0168 0 0.0165 0.0335 1 0.0330 0.0670 34 0.0125 0.0165 0.0335 30 1 0.0250 0.0165 0.0335 41 6 0.0250 0.0330 0.0670 83 37 0.0500 0.0083 0.0168 59 45 0.0500 0.0165 0.0335 53 46 0.0500 0.0330 0.0670 75 64 0.2000 0.0165 0.0335 87 79 Table B1.4: Rhizoctonia solani: 0.0125 0 0.0250 6 0.1000 0 0.0083 0.0168 1 0.0165 0.0335 88 0.0125 0.0165 0.0335 100 88 0.0250 0.0083 0.0168 59 7 0.0250 0.0165 0.0335 100 89 0.1000 0.0083 0.0168 51 1 Table B1.5: Septoria tritici: 0.0016 52 0.0010 0.0021 5 0.0021 0.0042 2 0.0016 0.0010 0.0021 79 55 0.0016 0.0021 0.0042 71 53

TABLE B2 The abbreviations are defined as follows: 1.001 = compound No. 1.001 STL = compound of formula VII DFZ = difenoconazole Solution of STL + DFZ expected Solution of 1.001 (3:5) observed % action ppm ppm ppm activity (colby) B2.1: Gaeumannomyces graminis 0.0125 0 0.0250 4 0.0500 0 0.1000 0 0.0188 0.0313 44 0.0125 0.0188 0.0313 89 44 0.0250 0.0188 0.0313 71 46 0.0500 0.0188 0.0313 64 44 0.1000 0.0188 0.0313 49 44 B2.2: Alternaria solani: 0.0016 39 0.0001 0.0002 0 0.0003 0.0005 1 0.0012 0.0020 4 0.0023 0.0039 1 0.0016 0.0001 0.0002 50 39 0.0016 0.0003 0.0005 48 39 0.0016 0.0012 0.0020 65 41 0.0016 0.0023 0.0039 66 39 B2.3: Monographella nivalis: 0.0250 0 0.0500 26 0.0047 0.0078 9 0.0094 0.0156 2 0.0188 0.0313 12 0.0375 0.0625 25 0.0250 0.0375 0.0625 81 25 0.0500 0.0047 0.0078 72 33 0.0500 0.0094 0.0156 65 27 0.0500 0.0188 0.0313 42 35 0.0500 0.0375 0.0625 78 45

TABLE B3 The abbreviations are defined as follows: 1.001 = compound No. 1.001 STL = compound of formula VII AZ = azoxystrobin Solution of STL + AZ expected Solution of 1.001 (1:2) observed % action ppm ppm ppm activity (colby) B3.1: Gaeumannomyces graminis 0.0031 0 0.0063 0 0.0125 8 0.0250 0 0.0500 0 0.0021 0.0042 12 0.0041 0.0084 42 0.0031 0.0041 0.0084 91 42 0.0063 0.0021 0.0042 38 12 0.0063 0.0041 0.0084 62 42 0.0125 0.0041 0.0084 90 47 0.0250 0.0021 0.0042 45 12 0.0250 0.0041 0.0084 93 42 0.0500 0.0041 0.0084 84 42 B3.2: Alternaria solani: 0.0016 45 0.0031 66 0.0003 0.0005 3 0.0005 0.0010 0 0.0010 0.0021 0 0.0016 0.0003 0.0005 67 47 0.0016 0.0010 0.0021 72 45 0.0031 0.0005 0.0010 81 66 B3.3: Fusarium culmorum: 0.0250 19 0.0500 48 0.1000 55 0.2000 59 0.0165 0.0335 6 0.0330 0.0670 0 0.0660 0.1340 0 0.0660 0.1340 0 0.0250 0.0165 0.0335 30 24 0.0500 0.0330 0.0670 56 48 0.0500 0.0660 0.1340 62 48 0.1000 0.0660 0.1340 63 55 0.2000 0.0660 0.1340 69 59 B3.4: Monographella nivalis: 0.0008 1 0.0010 0.0021 60 0.0008 0.0010 0.0021 77 61 B3.5: Septoria tritici: 0.0016 42 0.0031 83 0.0010 0.0021 0 0.0021 0.0042 4 0.0041 0.0084 17 0.0016 0.0010 0.0021 49 42 0.0016 0.0021 0.0042 65 45 0.0031 0.0041 0.0084 94 86

TABLE B4 The abbreviations are defined as follows: 1.001 = compound No. 1.001 STL = compound of formula VII PTC = prothioconazole Solution of STL + PTC expected Solution of 1.001 (1:2) observed % action ppm ppm ppm activity (colby) B4.1: Gaeumannomyces graminis 0.0125 0 0.0250 0 0.0500 0 0.1000 0 0.2000 12 0.0165 0.0335 24 0.0330 0.0670 88 0.0125 0.0165 0.0335 79 24 0.0250 0.0330 0.0670 100 88 0.0500 0.0165 0.0335 88 24 0.1000 0.0165 0.0335 62 24 0.2000 0.0165 0.0335 74 33 B4.2: Alternaria solani: 0.0008 29 0.0016 47 0.0031 73 0.0001 0.0003 0 0.0010 0.0021 0 0.0021 0.0042 0 0.0041 0.0084 3 0.0008 0.0010 0.0021 42 29 0.0016 0.0001 0.0003 63 47 0.0016 0.0021 0.0042 64 47 0.0031 0.0041 0.0084 86 74 B4.3: Monographella nivalis: 0.0500 15 0.1000 64 0.0083 0.0168 4 0.0165 0.0335 0 0.0500 0.0165 0.0335 83 15 0.1000 0.0083 0.0168 79 65

TABLE B5 The abbreviations are defined as follows: 1.001 = compound No. 1.001 STL = compound of formula VII TCZ = tebuconazole Solution of STL + observed expected Solution of 1.001 TCZ (1:2) % action ppm ppm ppm activity (colby) B5.1: Gaeumannomyces graminis 0.0250 0 0.0500 2 0.1000 0 0.2000 0 0.0165 0.0335 42 0.0330 0.0670 78 0.0250 0.0165 0.0335 57 42 0.0250 0.0330 0.0670 100 78 0.0500 0.0330 0.0670 98 78 0.1000 0.0165 0.0335 61 42 0.1000 0.0330 0.0670 98 78 0.2000 0.0165 0.0335 68 42 0.2000 0.0330 0.0670 89 78 B5.2: Alternaria solani: 0.0008 3 0.0016 36 0.0031 75 0.0005 0.0010 0 0.0010 0.0021 0 0.0021 0.0042 0 0.0008 0.0005 0.0010 31 3 0.0016 0.0010 0.0021 44 36 0.0016 0.0021 0.0042 64 36 0.0031 0.0010 0.0021 86 75 B5.3: Fusarium culmorum: 0.0250 9 0.0500 39 0.0021 0.0042 2 0.0041 0.0084 1 0.0083 0.0168 4 0.0250 0.0021 0.0042 32 11 0.0250 0.0041 0.0084 28 11 0.0500 0.0041 0.0084 52 40 0.0500 0.0083 0.0168 52 41 B5.4: Monographella nivalis: 0.0250 2 0.0500 9 0.1000 60 0.0083 0.0168 0 0.0165 0.0335 5 0.0330 0.0670 14 0.0660 0.1340 63 0.0250 0.0165 0.0335 25 7 0.0250 0.0330 0.0670 53 16 0.0500 0.0083 0.0168 29 9 0.0500 0.0165 0.0335 41 13 0.0500 0.0330 0.0670 65 22 0.0500 0.0660 0.1340 84 66 0.1000 0.0083 0.0168 70 60 0.1000 0.0165 0.0335 76 62 0.1000 0.0330 0.0670 85 66 B5.5: Rhizoctonia solani: 0.0250 13 0.0500 1 0.1000 17 0.0330 0.0670 0 0.0660 0.1340 28 0.0250 0.0330 0.0670 97 13 0.0500 0.0660 0.1340 87 29 0.1000 0.0660 0.1340 61 41 B5.6: Septoria tritici: 0.0008 27 0.0016 45 0.0031 82 0.0010 0.0021 0 0.0021 0.0042 5 0.0041 0.0084 0 0.0008 0.0010 0.0021 36 27 0.0016 0.0010 0.0021 70 45 0.0016 0.0021 0.0042 60 47 0.0031 0.0041 0.0084 91 82

TABLE B6 The abbreviations are defined as follows: 1.001 = compound No. 1.001 STL = compound of formula VII PYS = pyraclostrobin Solution of STL + observed expected Solution of 1.001 PYS (1:1) % action ppm ppm ppm activity (colby) B6.1: Gaeumannomyces graminis 0.0063 0 0.0250 0 0.1000 0 0.0125 0.0125 15 0.0063 0.0125 0.0125 34 15 0.0250 0.0125 0.0125 46 15 0.1000 0.0125 0.0125 84 15 B6.2: Alternaria solani: 0.0016 35 0.0031 71 0.0002 0.0002 0 0.0031 0.0031 0 0.0063 0.0063 0 0.0016 0.0002 0.0002 45 35 0.0016 0.0031 0.0031 46 35 0.0031 0.0063 0.0063 80 71 B6.3: Monographella nivalis: 0.0016 0 0.0031 3 0.0031 0.0031 4 0.0063 0.0063 78 0.0016 0.0031 0.0031 28 4 0.0031 0.0063 0.0063 92 78 B6.4: Septoria tritici: 0.0008 11 0.0016 53 0.0031 89 0.0002 0.0002 3 0.0016 0.0016 3 0.0031 0.0031 2 0.0063 0.0063 1 0.0008 0.0016 0.0016 28 14 0.0016 0.0002 0.0002 66 54 0.0016 0.0031 0.0031 69 54 0.0031 0.0063 0.0063 97 89

TABLE B7 The abbreviations are defined as follows: 1.001 = compound No. 1.001 STL = compound of formula VII TFS = trifloxystrobin Solution of STL + observed expected Solution of 1.001 TFS (1:1) % action ppm ppm ppm activity (colby) B7.1: Gaeumannomyces graminis 0.0063 0 0.0125 4 0.0250 2 0.0500 3 0.1000 0 0.2000 0 0.0125 0.0125 19 0.0250 0.0250 53 0.0063 0.0125 0.0125 71 19 0.0125 0.0250 0.0250 92 55 0.0250 0.0250 0.0250 90 54 0.0500 0.0125 0.0125 44 21 0.0500 0.0250 0.0250 74 55 0.1000 0.0250 0.0250 92 53 0.2000 0.0250 0.0250 92 53 B7.2: Alternaria solani: 0.0016 28 0.0031 66 0.0002 0.0002 4 0.0004 0.0004 0 0.0016 0.0016 0 0.0031 0.0031 0 0.0063 0.0063 5 0.0016 0.0002 0.0002 41 31 0.0016 0.0004 0.0004 42 28 0.0016 0.0016 0.0016 43 28 0.0016 0.0031 0.0031 57 28 0.0031 0.0004 0.0004 75 66 0.0031 0.0031 0.0031 76 66 0.0031 0.0063 0.0063 81 68 B7.3: Fusarium culmorum: 0.0125 11 0.0250 24 0.0500 49 0.1000 58 0.2000 60 0.0031 0.0031 2 0.0063 0.0063 0 0.0125 0.0125 1 0.0250 0.0250 9 0.0500 0.0500 5 0.1000 0.1000 10 0.0125 0.0250 0.0250 47 18 0.0250 0.0031 0.0031 38 25 0.0250 0.0063 0.0063 36 24 0.0250 0.0125 0.0125 35 24 0.0250 0.0250 0.0250 62 30 0.0250 0.0500 0.0500 69 28 0.0500 0.0063 0.0063 54 49 0.0500 0.0125 0.0125 62 49 0.0500 0.0250 0.0250 69 53 0.0500 0.0500 0.0500 77 52 0.0500 0.1000 0.1000 81 54 0.1000 0.0125 0.0125 65 58 0.1000 0.0250 0.0250 71 61 0.1000 0.0500 0.0500 75 60 0.1000 0.1000 0.1000 82 62 0.2000 0.0250 0.0250 75 63 0.2000 0.0500 0.0500 76 62 0.2000 0.1000 0.1000 83 64 B7.4: Rhizoctonia solani: 0.0125 3 0.0250 8 0.0125 0.0125 0 0.0125 0.0125 0.0125 96 3 0.0250 0.0125 0.0125 100 8 B7.5: Septoria tritici: 0.0016 53 0.0031 0.0031 42 0.0016 0.0031 0.0031 89 72

TABLE B8 The abbreviations are defined as follows: 1.001 = compound No. 1.001 STL = compound of formula VII FDL = fludioxonil Solution of STL + observed expected Solution of 1.001 FDL (1:4) % action ppm ppm ppm activity (colby) B8.1: Gaeumannomyces graminis 0.0250 0 0.0500 0 0.1000 0 0.2000 0 0.0100 0.0400 16 0.0200 0.0800 52 0.0250 0.0200 0.0800 100 52 0.0500 0.0200 0.0800 100 52 0.1000 0.0200 0.0800 100 52 0.2000 0.0100 0.0400 61 16 0.2000 0.0200 0.0800 96 52 B8.2: Alternaria solani: 0.0008 19 0.0016 42 0.0031 68 0.0006 0.0025 0 0.0013 0.0050 0 0.0025 0.0100 0 0.0008 0.0006 0.0025 40 19 0.0016 0.0013 0.0050 60 42 0.0031 0.0025 0.0100 80 68 B8.3: Fusarium culmorum: 0.0250 18 0.0500 51 0.2000 55 0.0100 0.0400 9 0.0200 0.0800 15 0.0250 0.0100 0.0400 42 25 0.0250 0.0200 0.0800 76 30 0.0500 0.0200 0.0800 91 58 0.2000 0.0200 0.0800 71 62

TABLE B9 The abbreviations are defined as follows: 1.001 = compound No. 1.001 STL = compound of formula VII CPL = cyprodinil Solution of STL + observed expected Solution of 1.001 CPL (1:4) % action ppm ppm ppm activity (colby) B9.1: Gaeumannomyces graminis 0.0125 0 0.0250 0 0.0500 0 0.1000 0 0.2000 0 0.0100 0.0400 0 0.0200 0.0800 30 0.0125 0.0100 0.0400 39 0 0.0250 0.0200 0.0800 88 30 0.0500 0.0200 0.0800 56 30 0.1000 0.0200 0.0800 55 30 0.2000 0.0200 0.0800 66 30 B9.2: Alternaria solani: 0.0016 37 0.0031 67 0.0002 0.0006 0 0.0013 0.0050 0 0.0025 0.0100 0 0.0016 0.0002 0.0006 41 37 0.0016 0.0013 0.0050 43 37 0.0031 0.0025 0.0100 75 67 B9.3: Rhizoctonia solani: 0.0500 0 0.2000 6 0.0200 0.0800 0 0.0500 0.0200 0.0800 99 0 0.2000 0.0200 0.0800 69 6

TABLE B10 The abbreviations are defined as follows: 1.001 = compound No. 1.001 STL = compound of formula VII FLN = fluazinam Solution of STL + observed expected Solution of 1.001 FLN (1:6) % action ppm ppm ppm activity (colby) B10.1: Gaeumannomyces graminis 0.0125 0 0.0250 0 0.0500 0 0.1000 0 0.2000 0 0.0036 0.0214 3 0.0072 0.0428 40 0.0143 0.0857 91 0.0286 0.1714 90 0.0125 0.0072 0.0428 83 40 0.0250 0.0072 0.0428 89 40 0.0250 0.0143 0.0857 100 91 0.0500 0.0286 0.1714 100 90 0.1000 0.0036 0.0214 51 3 0.1000 0.0286 0.1714 100 90 0.2000 0.0072 0.0428 76 40 B10.2: Alternaria solani: 0.0016 38 0.0001 0.0003 0 0.0009 0.0054 0 0.0016 0.0001 0.0003 55 38 0.0016 0.0009 0.0054 52 38 B10.3: Monographella nivalis: 0.0063 0 0.0125 0 0.0250 0 0.0500 16 0.1000 61 0.2000 85 0.0036 0.0214 8 0.0072 0.0428 37 0.0063 0.0036 0.0214 26 8 0.0125 0.0072 0.0428 98 37 0.0250 0.0072 0.0428 95 38 0.0500 0.0072 0.0428 84 47 0.1000 0.0036 0.0214 82 64 0.1000 0.0072 0.0428 94 76 0.2000 0.0072 0.0428 100 90 B10.4: Rhizoctonia solani: 0.0250 0 0.0500 0 0.0143 0.0857 0 0.0250 0.0143 0.0857 100 0 0.0500 0.0143 0.0857 71 0

TABLE B11 The abbreviations are defined as follows: 1.001 = compound No. 1.001 IZM = isopyrazam DFZ: difenoconazole Solution of IZM + observed expected Solution of 1.001 DFZ (1:1) % action ppm ppm ppm activity (colby) B11.1: Gaeumannomyces graminis: 0.1000 0 0.0500 0.0500 0 0.1000 0.0500 0.0500 57 0 B11.2: Alternaria solani: 0.0008 24 0.0016 48 0.0016 0.0016 10 0.0031 0.0031 9 0.0008 0.0016 0.0016 45 31 0.0016 0.0031 0.0031 63 53 B11.3: Monographella nivalis: 0.0500 36 0.1000 69 0.0063 0.0063 0 0.0125 0.0125 0 0.1000 0.1000 2 0.0500 0.0063 0.0063 54 36 0.1000 0.0125 0.0125 82 69 0.1000 0.1000 0.1000 89 70 B11.4: Rhizoctonia solani: 0.0125 0 0.0250 8 0.0500 0 0.2000 0 0.0250 0.0250 17 0.0500 0.0500 36 0.0125 0.0250 0.0250 37 17 0.0250 0.0500 0.0500 52 41 0.0500 0.0500 0.0500 72 36 0.2000 0.0250 0.0250 44 17 0.2000 0.0500 0.0500 56 36

TABLE B12 The abbreviations are defined as follows: 1.001 = compound No. 1.001 IZM = isopyrazam AZO: azoxystrobin Solution of IZM + observed expected Solution of 1.001 AZO (1:1) % action ppm ppm ppm activity (colby) B12.1: Gaeumannomyces graminis: 0.0016 0 0.0031 0 0.0063 0 0.0125 0 0.0031 0.0031 45 0.0016 0.0031 0.0031 79 45 0.0031 0.0031 0.0031 92 45 0.0063 0.0031 0.0031 68 45 0.0125 0.0031 0.0031 80 45 B12.2: Alternaria solani: 0.0008 33 0.0016 46 0.0002 0.0002 5 0.0016 0.0016 8 0.0031 0.0031 14 0.0008 0.0016 0.0016 58 38 0.0016 0.0002 0.0002 78 48 0.0016 0.0031 0.0031 77 53 B12.3: Monographella nivalis: 0.0031 1 0.0063 1 0.0250 0 0.0500 29 0.0063 0.0063 79 0.0031 0.0063 0.0063 100 79 0.0063 0.0063 0.0063 93 79 0.0250 0.0063 0.0063 100 79 0.0500 0.0063 0.0063 98 85 B12.4: Rhizoctonia solani: 0.0063 0 0.0125 0 0.0250 0 0.0500 0 0.1000 3 0.2000 17 0.0125 0.0125 54 0.0250 0.0250 69 0.0500 0.0500 85 0.0063 0.0125 0.0125 91 54 0.0125 0.0250 0.0250 88 69 0.0250 0.0250 0.0250 96 69 0.0250 0.0500 0.0500 100 85 0.0500 0.0125 0.0125 60 54 0.0500 0.0250 0.0250 76 69 0.0500 0.0500 0.0500 95 85 0.1000 0.0250 0.0250 84 70 0.1000 0.0500 0.0500 100 85 0.2000 0.0250 0.0250 87 74 0.2000 0.0500 0.0500 99 87

TABLE B13 The abbreviations are defined as follows: 1.001 = compound No. 1.001 IZM = isopyrazam PTC: prothioconazole Solution of IZM + observed expected Solution of 1.001 PTC (1:1) % action ppm ppm ppm activity (colby) B13.1: Alternaria solani: 0.0008 20 0.0016 51 0.0031 78 0.0004 0.0004 16 0.0008 0.0008 5 0.0016 0.0016 10 0.0031 0.0031 12 0.0008 0.0004 0.0004 45 32 0.0008 0.0008 0.0008 48 23 0.0008 0.0016 0.0016 60 27 0.0016 0.0016 0.0016 65 56 0.0016 0.0031 0.0031 65 57 0.0031 0.0004 0.0004 96 82 B13.2: Monographella nivalis: 0.0250 8 0.1000 61 0.0125 0.0125 0 0.0500 0.0500 21 0.0250 0.0500 0.0500 51 27 0.1000 0.0125 0.0125 87 61 B13.3: Rhizoctonia solani: 0.0250 0 0.0500 0 0.2000 0 0.0500 0.0500 37 0.0250 0.0500 0.0500 55 37 0.0500 0.0500 0.0500 58 37 0.2000 0.0500 0.0500 61 37

TABLE B14 The abbreviations are defined as follows: 1.001 = compound No. 1.001 IZM = isopyrazam TCZ: tebuconazole Solution of IZM + TCZ expected Solution of 1.001 (1:1) observed action ppm ppm ppm % activity (colby) B14.1: Gaeumannomyces graminis: 0.1000 12 0.2000 0 0.1000 0.1000 0 0.1000 0.1000 51 0.1000 0.1000 0.1000 76 57 0.2000 0.1000 0.1000 100 51 B14.2: Alternaria solani: 0.0004 9 0.0008 24 0.0016 52 0.0031 83 0.0002 0.0002 7 0.0004 0.0004 7 0.0008 0.0008 9 0.0016 0.0016 6 0.0031 0.0031 17 0.0004 0.0004 0.0004 24 15 0.0008 0.0008 0.0008 37 31 0.0008 0.0016 0.0016 49 29 0.0016 0.0002 0.0002 73 56 0.0016 0.0016 0.0016 62 55 0.0016 0.0031 0.0031 80 61 0.0031 0.0004 0.0004 94 84 B14.3: Monographella nivalis: 0.0500 17 0.1000 67 0.0063 0.0063 0 0.0125 0.0125 0 0.0500 0.0063 0.0063 34 17 0.1000 0.0125 0.0125 81 67 B14.4: Rhizoctonia solani: 0.0125 0 0.0250 0 0.0500 3 0.1000 7 0.0250 0.0250 28 0.0500 0.0500 76 0.1000 0.1000 78 0.0125 0.0250 0.0250 57 28 0.0250 0.0500 0.0500 87 76 0.0500 0.1000 0.1000 97 78 0.1000 0.1000 0.1000 89 79

TABLE B15 The abbreviations are defined as follows: 1.001 = compound No. 1.001 IZM = isopyrazam PYS: pyraclostrobin Solution of IZM + PYS expected Solution of 1.001 (2:1) observed action ppm ppm ppm % activity (colby) B15.1: Alternaria solani: 0.0008 36 0.0016 56 0.0031 82 0.0005 0.0003 2 0.0010 0.0005 11 0.0021 0.0010 0 0.0042 0.0021 10 0.0008 0.0021 0.0010 65 36 0.0016 0.0005 0.0003 79 57 0.0016 0.0010 0.0005 79 61 0.0016 0.0021 0.0010 78 56 0.0016 0.0042 0.0021 82 60 0.0031 0.0042 0.0021 94 84 B15.2: Monographella nivalis: 0.0500 17 0.1000 63 0.0168 0.0083 27 0.0500 0.0168 0.0083 54 40 0.1000 0.0168 0.0083 94 73 B15.3: Rhizoctonia solani: 0.0031 5 0.0063 0 0.0125 0 0.0250 0 0.0500 9 0.0084 0.0041 11 0.0168 0.0083 58 0.0031 0.0084 0.0041 37 15 0.0063 0.0084 0.0041 49 11 0.0063 0.0168 0.0083 72 58 0.0125 0.0084 0.0041 43 11 0.0125 0.0168 0.0083 87 58 0.0250 0.0084 0.0041 50 11 0.0250 0.0168 0.0083 72 58 0.0500 0.0084 0.0041 40 19 0.0500 0.0168 0.0083 77 62

TABLE B16 The abbreviations are defined as follows: 1.001 = compound No. 1.001 IZM = isopyrazam TFS: trifloxystrobin Solution of IZM + TFS expected Solution of 1.001 (2:1) observed action ppm ppm ppm % activity (colby) B16.1: Gaeumannomyces graminis: 0.2000 16 0.0670 0.0330 14 0.1340 0.0660 14 0.2000 0.0670 0.0330 75 28 0.2000 0.1340 0.0660 85 60 B16.2: Alternaria solani: 0.0008 40 0.0005 0.0003 0 0.0010 0.0005 0 0.0021 0.0010 12 0.0008 0.0005 0.0003 50 40 0.0008 0.0010 0.0005 52 40 0.0008 0.0021 0.0010 60 47 B16.3: Fusarium culmorum: 0.0250 26 0.0500 46 0.1000 50 0.2000 56 0.0084 0.0041 6 0.0335 0.0165 9 0.0670 0.0330 4 0.1340 0.0660 4 0.1340 0.0660 2 0.0250 0.0084 0.0041 41 30 0.0250 0.0335 0.0165 46 32 0.0250 0.0670 0.0330 68 28 0.0500 0.0335 0.0165 58 51 0.0500 0.0670 0.0330 70 48 0.0500 0.1340 0.0660 78 47 0.1000 0.0670 0.0330 62 52 0.1000 0.1340 0.0660 77 51 0.2000 0.0335 0.0165 67 60 0.2000 0.0670 0.0330 66 57 0.2000 0.1340 0.0660 75 57 B16.4: Monographella nivalis: 0.0004 2 0.0010 0.0005 42 0.0004 0.0010 0.0005 64 44 B16.5: Rhizoctonia solani: 0.0063 0 0.0125 0 0.0250 0 0.0500 11 0.1000 0 0.0084 0.0041 0 0.0168 0.0083 3 0.0063 0.0168 0.0083 88 3 0.0125 0.0084 0.0041 35 0 0.0250 0.0168 0.0083 74 3 0.0500 0.0168 0.0083 45 14 0.1000 0.0168 0.0083 64 3

TABLE B17 The abbreviations are defined as follows: 1.001 = compound No. 1.001 IZM = isopyrazam FDL: fludioxonil Solution of IZM + FDL expected Solution of 1.001 (1:2) observed action ppm ppm ppm % activity (colby) B17.1: Alternaria solani 0.0008 25 0.0016 57 0.0001 0.0003 0 0.0003 0.0005 9 0.0010 0.0021 1 0.0021 0.0042 0 0.0008 0.0001 0.0003 49 25 0.0008 0.0003 0.0005 42 32 0.0008 0.0010 0.0021 44 26 0.0016 0.0001 0.0003 79 57 0.0016 0.0010 0.0021 78 57 0.0016 0.0021 0.0042 76 57 B17.2: Fusarium culmorum: 0.0063 9 0.0125 16 0.0250 27 0.0500 46 0.2000 54 0.0041 0.0084 3 0.0083 0.0168 6 0.0165 0.0335 0 0.0330 0.0670 2 0.0660 0.1340 2 0.0660 0.1340 48 0.0063 0.0083 0.0168 48 15 0.0125 0.0165 0.0335 28 16 0.0250 0.0165 0.0335 96 27 0.0250 0.0330 0.0670 60 28 0.0500 0.0041 0.0084 55 48 0.0500 0.0330 0.0670 79 47 0.0500 0.0660 0.1340 100 72 0.2000 0.0660 0.1340 100 76 B17.3: Monographella nivalis: 0.1000 73 0.0083 0.0168 0 0.1000 0.0083 0.0168 80 73 B17.4: Rhizoctonia solani: 0.0250 0 0.0500 6 0.1000 0 0.0330 0.0670 81 0.0250 0.0330 0.0670 96 81 0.0500 0.0330 0.0670 96 82 0.1000 0.0330 0.0670 96 81

TABLE B18 The abbreviations are defined as follows: 1.001 = compound No. 1.001 IZM = isopyrazam CPL: cyprodinil Solution of IZM + CPL expected Solution of 1.001 (1:2) observed action ppm ppm ppm % activity (colby) B18.1: Alternaria solani 0.0016 60 0.0001 0.0003 12 0.0003 0.0005 1 0.0010 0.0021 1 0.0021 0.0042 8 0.0016 0.0001 0.0003 73 65 0.0016 0.0003 0.0005 67 61 0.0016 0.0010 0.0021 68 60 0.0016 0.0021 0.0042 72 63 B18.2: Monographella nivalis: 0.0031 0 0.0063 0 0.0041 0.0084 24 0.0031 0.0041 0.0084 78 24 0.0063 0.0041 0.0084 51 24 B18.3: Rhizoctonia solani: 0.0125 20 0.0250 0 0.0500 0 0.0165 0.0335 47 0.0125 0.0165 0.0335 77 58 0.0250 0.0165 0.0335 71 47 0.0500 0.0165 0.0335 54 47 B18.4: Septoria tritici: 0.0016 62 0.0001 0.0003 0 0.0016 0.0001 0.0003 69 62

TABLE B19 The abbreviations are defined as follows: 1.001 = compound No. 1.001 IZM = isopyrazam FLN: fluazinam Solution of IZM + FLN expected Solution of 1.001 (1:3) observed action ppm ppm ppm % activity (colby) B19.1: Gaeumannomyces graminis: 0.0500 0 0.1000 1 0.2000 0 0.0500 0.1500 76 0.0500 0.1500 30 0.0500 0.0500 0.1500 95 30 0.1000 0.0500 0.1500 83 31 0.2000 0.0500 0.1500 90 30 B19.2: Alternaria solani: 0.0004 11 0.0008 29 0.0016 65 0.0001 0.0003 5 0.0002 0.0006 0 0.0004 0.0012 16 0.0008 0.0023 16 0.0016 0.0047 10 0.0004 0.0001 0.0003 28 15 0.0008 0.0001 0.0003 47 33 0.0008 0.0004 0.0012 46 40 0.0008 0.0008 0.0023 46 40 0.0016 0.0002 0.0006 72 65 0.0016 0.0016 0.0047 78 69 B19.3: Monographella nivalis: 0.0250 3 0.0500 12 0.1000 63 0.2000 90 0.0063 0.0188 3 0.0250 0.0750 8 0.0250 0.0250 0.0750 95 10 0.0500 0.0250 0.0750 55 19 0.1000 0.0063 0.0188 80 65 0.1000 0.0250 0.0750 92 66 0.2000 0.0250 0.0750 100 90

TABLE B20 The abbreviations are defined as follows: 1.001 = compound No. 1.001 DFZ = difenoconazole AZO: azoxystrobin Solution of DFZ + AZO expected Solution of 1.001 (1:1) observed action ppm ppm ppm % activity (colby) B20.1: Gaeumannomyces graminis: 0.0125 0 0.0250 0 0.0500 0 0.2000 0 0.0125 0.0125 54 0.0250 0.0250 42 0.0125 0.0125 0.0125 60 54 0.0125 0.0250 0.0250 72 42 0.0250 0.0250 0.0250 76 42 0.0500 0.0250 0.0250 79 42 0.2000 0.0250 0.0250 63 42 B20.2: Monographella nivalis: 0.0500 6 0.0063 0.0063 39 0.0500 0.0063 0.0063 79 42 B20.3: Rhizoctonia solani: 0.0500 0 0.0500 0.0500 33 0.0500 0.0500 0.0500 52 33 B20.4: Septoria tritici: 0.0016 35 0.0004 0.0004 5 0.0016 0.0004 0.0004 47 38

TABLE B21 The abbreviations are defined as follows: 1.001 = compound No. 1.001 DFZ = difenoconazole PTC = prothioconazole B21.1: Rhizoctonia solani: Solution of DFZ + PTC expected Solution of 1.001 (1:1) observed action ppm ppm ppm % activity (colby) 0.0500 0 0.1000 0.1000 15 0.0500 0.1000 0.1000 52 15

TABLE B22 The abbreviations are defined as follows: 1.001 = compound No. 1.001 DFZ = difenoconazole TCZ = tebuconazole B22.1: Monographella nivalis: Solution of DFZ + TCZ expected Solution of 1.001 (1:1) observed action ppm ppm ppm % activity (colby) 0.1000 46 0.0125 0.0125 1 0.1000 0.0125 0.0125 59 46

TABLE B23 The abbreviations are defined as follows: 1.001 = compound No. 1.001 DFZ = difenoconazole PYS = pyraclostrobin B23.1: Monographella nivalis: Solution of DFZ + PYS expected Solution of 1.001 (2:1) observed action ppm ppm ppm % activity (colby) 0.0250 0 0.0500 6 0.0670 0.0330 58 0.0250 0.0670 0.0330 85 58 0.0500 0.0670 0.0330 87 61

TABLE B24 The abbreviations are defined as follows: 1.001 = compound No. 1.001 DFZ = difenoconazole TFS = trifloxystrobin Solution of DFZ + TFS expected Solution of 1.001 (2:1) observed action ppm ppm ppm % activity (colby) B24.1: Alternaria solani 0.0016 40 0.0003 0.0001 0 0.0016 0.0003 0.0001 66 40 B24.2: Monographella nivalis: 0.0008 0 0.0016 0 0.0031 0 0.0063 0 0.0010 0.0005 15 0.0021 0.0010 49 0.0042 0.0021 79 0.0008 0.0010 0.0005 27 15 0.0016 0.0021 0.0010 64 49 0.0016 0.0042 0.0021 92 79 0.0031 0.0042 0.0021 90 79 0.0063 0.0042 0.0021 94 79 B24.3: Botrytis cinerea: 0.0063 69 0.0125 83 0.0168 0.0083 24 0.0063 0.0168 0.0083 85 77 0.0125 0.0168 0.0083 98 87

TABLE B25 The abbreviations are defined as follows: 1.001 = compound No. 1.001 DFZ = difenoconazole FDL = Fludioxonil Solution of DFZ + FDL expected Solution of 1.001 (1:2) observed % action ppm ppm ppm activity (colby) B25.1: Fusarium culmorum 0.0250 27 0.0500 50 0.0165 0.0335 8 0.0330 0.0670 10 0.0660 0.1340 75 0.0250 0.0165 0.0335 51 33 0.0500 0.0330 0.0670 88 55 0.0500 0.0660 0.1340 99 87 B25.2. Botrytis cinera 0.0031 54 0.0063 69 0.0125 84 0.0041 0.0084 11 0.0083 0.0168 22 0.0031 0.0041 0.0084 65 59 0.0063 0.0041 0.0084 91 72 0.0063 0.0083 0.0168 100 76 0.0125 0.0041 0.0084 96 86 0.0125 0.0083 0.0168 100 88

TABLE B26 The abbreviations are defined as follows: 1.001 = compound No. 1.001 DFZ = difenoconazole CPL = Cyprodinil Solution of DFZ + CPL + expected Solution of 1.001 (1:2) observed % action ppm ppm ppm activity (colby) B26.1: Altnernaria solani 0.0016 57 0.0001 0.0003 0 0.0016 0.0001 0.0003 67 57 B26.2: Fusarium culmorum 0.0250 29 0.0021 0.0042 4 0.0250 0.0021 0.0042 47 32

TABLE B27 The abbreviations are defined as follows: 1.001 = compound No. 1.001 DFZ = difenoconazole FLN = Fluazinam Solution of DFZ + FLN expected Solution of 1.001 (1:3) observed % action ppm ppm ppm activity (colby) B27.1: Fusarium culmorum 0.0250 27 0.0500 49 0.0016 0.0047 6 0.0031 0.0094 4 0.0250 0.0016 0.0047 41 32 0.0500 0.0031 0.0094 57 51 B27.2: Monographella nivalis 0.0500 6 0.1000 27 0.2000 87 0.0500 0.1500 0 0.0500 0.0500 0.1500 78 6 0.1000 0.0500 0.1500 83 27 0.2000 0.0500 0.1500 97 87 B27.3: Botrytis cinerea 0.0016 49 0.0031 57 0.0063 63 0.0125 89 0.0004 0.0012 3 0.0016 0.0047 2 0.0031 0.0094 2 0.0063 0.0188 5 0.0125 0.0375 6 0.0016 0.0016 0.0047 74 50 0.0031 0.0031 0.0094 84 58 0.0063 0.0004 0.0012 74 65 0.0063 0.0031 0.0094 85 64 0.0063 0.0063 0.0188 100 65 0.0125 0.0063 0.0188 99 89 0.0125 0.0125 0.0375 100 89

TABLE B28 The abbreviations are defined as follows: 1.001 = compound No. 1.001 AZ = azoxystrobin PTC = Prothioconazole Solution of AZO + PTC expected Solution of 1.001 (1:1) observed % action ppm ppm ppm activity (colby) B28.1: Gäumannomyces graminis 0.0031 0 0.0125 0 0.0250 0 0.0500 0 0.1000 0 0.2000 0 0.0063 0.0063 17 0.0250 0.0250 60 0.0500 0.0500 66 0.1000 0.1000 66 0.1000 0.1000 66 0.0031 0.0063 0.0063 40 17 0.0125 0.0250 0.0250 67 60 0.0250 0.0063 0.0063 41 17 0.0250 0.0500 0.0500 76 66 0.0500 0.1000 0.1000 77 66 0.1000 0.0250 0.0250 71 60 0.1000 0.1000 0.1000 75 66 0.2000 0.1000 0.1000 78 66 B28.2: Alternaria solani 0.0016 24 0.0002 0.0002 5 0.0016 0.0016 6 0.0016 0.0002 0.0002 40 28 0.0016 0.0016 0.0016 44 29 B28.3: Fusarium culmorum 0.0500 55 0.1000 56 0.1000 0.1000 55 0.0500 0.1000 0.1000 100 80 0.1000 0.1000 0.1000 97 80 B28.4: Monographella nivalis 0.0016 0 0.0031 2 0.0125 2 0.0500 6 0.0031 0.0031 18 0.0063 0.0063 63 0.0016 0.0031 0.0031 45 18 0.0031 0.0063 0.0063 93 64 0.0125 0.0063 0.0063 73 64 0.0500 0.0063 0.0063 95 65

TABLE B29 The abbreviations are defined as follows: 1.001 = compound No. 1.001 AZ = azoxystrobin TCZ = Tebuconazole Solution of AZO + TCZ expected Solution of 1.001 (1:1) observed % action ppm ppm ppm activity (colby) B29.1: Gäumannomyces graminis 0.0250 2 0.0500 0 0.1000 0 0.2000 0 0.0031 0.0031 4 0.0250 0.0250 44 0.0500 0.0500 69 0.0250 0.0031 0.0031 41 6 0.0250 0.0250 0.0250 58 45 0.0500 0.0250 0.0250 66 44 0.0500 0.0500 0.0500 79 69 0.1000 0.0500 0.0500 78 69 0.2000 0.0250 0.0250 53 44 B29.2: Monographella nivalis 0.0250 0 0.0063 0.0063 62 0.0250 0.0063 0.0063 73 62 B29.3: Septoria tritici 0.0008 17 0.0016 40 0.0031 88 0.0016 0.0016 0 0.0031 0.0031 12 0.0063 0.0063 3 0.0008 0.0016 0.0016 22 17 0.0016 0.0031 0.0031 68 47 0.0031 0.0063 0.0063 95 89

TABLE B30 The abbreviations are defined as follows: 1.001 = compound No. 1.001 AZ = azoxystrobin PYS = Pyraclostrobin Solution of AZO + PYS expected Solution of 1.001 (2:1) observed % action ppm ppm ppm activity (colby) B30.1: Gäumannomyces graminis 0.0031 7 0.0125 0 0.0250 0 0.0500 1 0.1000 4 0.2000 0 0.0084 0.0041 40 0.0168 0.0083 51 0.0335 0.0165 55 0.0670 0.0330 53 0.1340 0.0660 53 0.1340 0.0660 62 0.0031 0.0084 0.0041 52 45 0.0125 0.0168 0.0083 60 51 0.0125 0.0335 0.0165 66 55 0.0250 0.0084 0.0041 53 40 0.0250 0.0335 0.0165 72 55 0.0250 0.0670 0.0330 80 53 0.0500 0.0335 0.0165 64 56 0.0500 0.0670 0.0330 66 54 0.1000 0.0335 0.0165 72 57 0.1000 0.0670 0.0330 69 55 0.1000 0.1340 0.0660 75 63 0.2000 0.0335 0.0165 64 55 0.2000 0.0670 0.0330 61 53 0.2000 0.1340 0.0660 68 62 B30.2: Alternaria solani 0.0016 31 0.0021 0.0010 11 0.0042 0.0021 7 0.0016 0.0021 0.0010 58 38 0.0016 0.0042 0.0021 58 36 B30.3: Fusarium culmorum 0.0250 28 0.0500 55 0.1000 56 0.0670 0.0330 0 0.1340 0.0660 8 0.0250 0.0670 0.0330 43 28 0.0500 0.0670 0.0330 61 55 0.0500 0.1340 0.0660 66 58 0.1000 0.1340 0.0660 69 60 B30.4: Monographella nivalis 0.0016 0 0.0031 0 0.0021 0.0010 31 0.0042 0.0021 52 0.0016 0.0021 0.0010 61 31 0.0016 0.0042 0.0021 61 52 0.0031 0.0042 0.0021 82 52

TABLE B31 The abbreviations are defined as follows: 1.001 = compound No. 1.001 AZ = azoxystrobin TFS = Trifloxystrobin Solution of AZO + TFS expected Solution of 1.001 (2:1) observed % action ppm ppm ppm activity (colby) B31.1: Gäumannomyces graminis 0.0063 0 0.0125 0 0.0250 4 0.0500 0 0.2000 3 0.0084 0.0041 41 0.0168 0.0083 61 0.0335 0.0165 44 0.0063 0.0084 0.0041 51 41 0.0063 0.0168 0.0083 67 61 0.0125 0.0084 0.0041 56 41 0.0125 0.0168 0.0083 69 61 0.0125 0.0335 0.0165 76 44 0.0250 0.0335 0.0165 75 46 0.0500 0.0335 0.0165 53 44 0.2000 0.0335 0.0165 72 46 B31.2: Alternaria solani 0.0008 1 0.0003 0.0001 0 0.0005 0.0003 5 0.0010 0.0005 0 0.0008 0.0003 0.0001 39 1 0.0008 0.0005 0.0003 34 5 0.0008 0.0010 0.0005 42 1 B31.3: Fusarium culmorum 0.0125 11 0.0250 29 0.0500 52 0.1000 52 0.2000 59 0.0335 0.0165 11 0.0670 0.0330 7 0.1340 0.0660 7 0.0125 0.0335 0.0165 42 20 0.0250 0.0335 0.0165 58 36 0.0250 0.0670 0.0330 73 34 0.0500 0.0335 0.0165 64 57 0.0500 0.0670 0.0330 74 56 0.0500 0.1340 0.0660 77 56 0.1000 0.0670 0.0330 72 55 0.1000 0.1340 0.0660 78 55 0.2000 0.0670 0.0330 71 62 0.2000 0.1340 0.0660 75 62 B31.4: Monographella nivalis 0.0004 0 0.0008 0 0.0010 0.0005 37 0.0004 0.0010 0.0005 64 37 0.0008 0.0010 0.0005 55 37 B31.5: Septoria tritici 0.0016 44 0.0042 0.0021 65 0.0016 0.0042 0.0021 95 80 B31.6: Botrytis cinerea 0.0008 29 0.0016 51 0.0021 0.0010 18 0.0042 0.0021 34 0.0008 0.0021 0.0010 65 42 0.0016 0.0042 0.0021 76 68

TABLE B32 The abbreviations are defined as follows: 1.001 = compound No. 1.001 AZ = azoxystrobin FDL = Fludioxonil Solution of AZO + FDL expected Solution of 1.001 (1:2) observed % action ppm ppm ppm activity (colby) B32.1: Gäumannomyces graminis 0.0063 10 0.0125 1 0.0250 6 0.0500 0 0.1000 0 0.2000 0 0.0041 0.0084 11 0.0083 0.0168 34 0.0165 0.0335 55 0.0660 0.1340 63 0.0063 0.0041 0.0084 35 20 0.0125 0.0041 0.0084 38 11 0.0125 0.0083 0.0168 63 35 0.0250 0.0083 0.0168 48 38 0.0500 0.0660 0.1340 70 63 0.1000 0.0083 0.0168 49 34 0.1000 0.0165 0.0335 63 55 0.2000 0.0165 0.0335 66 55 B32.2: Alternaria solani 0.0016 38 0.0031 69 0.0003 0.0005 0 0.0005 0.0010 0 0.0010 0.0021 1 0.0021 0.0042 0 0.0016 0.0003 0.0005 69 38 0.0016 0.0005 0.0010 45 38 0.0016 0.0021 0.0042 74 38 0.0031 0.0010 0.0021 77 69 B32.3: Fusarium culmorum 0.0250 24 0.0500 51 0.1000 55 0.2000 57 0.0330 0.0670 0 0.0660 0.1340 0 0.0660 0.1340 10 0.0250 0.0330 0.0670 47 24 0.0500 0.0330 0.0670 84 51 0.0500 0.0660 0.1340 83 56 0.1000 0.0330 0.0670 71 55 0.1000 0.0660 0.1340 95 59 0.2000 0.0330 0.0670 65 57 0.2000 0.0660 0.1340 91 61 B32.4: Rhizoctonia solani 0.0500 11 0.1000 10 0.0330 0.0670 0 0.0660 0.1340 20 0.0500 0.0330 0.0670 58 11 0.0500 0.0660 0.1340 76 29 0.1000 0.0660 0.1340 94 28 B32.5: Botrytis cinerea 0.0031 63 0.0063 85 0.0041 0.0084 10 0.0083 0.0168 36 0.0031 0.0041 0.0084 79 66 0.0063 0.0083 0.0168 100 90

TABLE B33 The abbreviations are defined as follows: 1.001 = compound No. 1.001 AZ = azoxystrobin CPL = Cyprodinil Solution of AZO + CPL expected Solution of 1.001 (1:2) observed % action ppm ppm ppm activity (colby) B33.1: Gäumannomyces graminis 0.0125 0 0.0250 0 0.0500 0 0.1000 0 0.2000 2 0.0083 0.0168 50 0.0165 0.0335 43 0.0330 0.0670 56 0.0125 0.0083 0.0168 65 50 0.0125 0.0165 0.0335 81 43 0.0250 0.0165 0.0335 65 43 0.0250 0.0330 0.0670 83 56 0.0500 0.0330 0.0670 73 56 0.1000 0.0165 0.0335 61 43 0.2000 0.0330 0.0670 64 57 B33.2: Alternaria solani 0.0008 9 0.0016 44 0.0001 0.0003 0 0.0003 0.0005 3 0.0008 0.0001 0.0003 26 9 0.0008 0.0003 0.0005 35 11 0.0016 0.0003 0.0005 53 45 B33.3: Monographella nivalis 0.0031 0 0.0063 0 0.0125 0 0.0041 0.0084 29 0.0031 0.0041 0.0084 61 29 0.0063 0.0041 0.0084 58 29 0.0125 0.0041 0.0084 43 29

TABLE B34 The abbreviations are defined as follows: 1.001 = compound No. 1.001 AZ = azoxystrobin FLN = Fluazinam Solution of AZO + FLN expected Solution of 1.001 (1:3) observed % action ppm ppm ppm activity (colby) B34.1: Gäumannomyces graminis 0.0063 0 0.0125 0 0.0250 4 0.0500 0 0.2000 0 0.0063 0.0188 20 0.0125 0.0375 48 0.0250 0.0750 57 0.0063 0.0063 0.0188 55 20 0.0125 0.0063 0.0188 50 20 0.0125 0.0125 0.0375 71 48 0.0250 0.0250 0.0750 77 59 0.0500 0.0250 0.0750 74 57 0.2000 0.0250 0.0750 81 57 B34.2: Monographella nivalis 0.0031 0 0.0063 0 0.0125 0 0.0250 0 0.0031 0.0094 17 0.0031 0.0031 0.0094 98 17 0.0063 0.0031 0.0094 71 17 0.0125 0.0031 0.0094 51 17 0.0250 0.0031 0.0094 42 17 B34.3: Septoria tritici 0.0008 36 0.0016 53 0.0008 0.0023 2 0.0016 0.0047 6 0.0008 0.0008 0.0023 54 37 0.0016 0.0016 0.0047 75 56 B34.4: Botrytis cinerea 0.0031 73 0.0031 0.0094 2 0.0031 0.0031 0.0094 90 74

TABLE B35 The abbreviations are defined as follows: 1.001 = compound No. 1.001 PTC = Prothioconazole TCZ = Tebuconazole Solution of Solution of PTC + TCZ expected 1.001 1:1 observed % action ppm ppm ppm activity (colby) B35.1: Gäumannomyces graminis 0.0250 7 0.0500 9 0.1000 17 0.0500 0.0500 0 0.1000 0.1000 53 0.0250 0.0500 0.0500 57 7 0.0500 0.1000 0.1000 88 58 0.1000 0.1000 0.1000 100 61 B35.2: Alternaria solani 0.0016 7 0.0063 75 0.0031 0.0031 13 0.0063 0.0063 6 0.0016 0.0031 0.0031 44 19 0.0063 0.0031 0.0031 87 78 0.0063 0.0063 0.0063 89 76 B35.3: Fusarium culmorum 0.0125 7 0.0250 46 0.0250 0.0250 31 0.0500 0.0500 40 0.0125 0.0250 0.0250 59 36 0.0250 0.0500 0.0500 100 67 B35.4: Monographella nivalis 0.0125 0 0.0250 0.0250 0 0.0125 0.0250 0.0250 91 0

TABLE B36 The abbreviations are defined as follows: 1.001 = compound No. 1.001 PTC = Prothioconazole PYS = Pyraclostrobin Solution of Solution of PTC + PYS expected 1.001 2:1 observed % action ppm ppm ppm activity (colby) B36.1: Gäumannomyces graminis 0.0500 7 0.1340 0.0660 41 0.0500 0.1340 0.0660 100 46 B36.2: Fusarium culmorum 0.0250 29 0.0042 0.0021 1 0.0250 0.0042 0.0021 46 30 B36.3: Monographella nivalis 0.0031 2 0.0063 0 0.0084 0.0041 30 0.0168 0.0083 90 0.0031 0.0084 0.0041 51 32 0.0063 0.0084 0.0041 39 30 0.0063 0.0168 0.0083 99 90

TABLE B37 The abbreviations are defined as follows: 1.001 = compound No. 1.001 PTC = Prothioconazole TFS = Trifloxystrobin Solution of Solution of PTC + TFS expected 1.001 2:1 observed % action ppm ppm ppm activity (colby) B37.1: Fusarium culmorum 0.0125 10 0.0250 27 0.0335 0.0165 16 0.0670 0.0330 41 0.0125 0.0335 0.0165 39 24 0.0250 0.0670 0.0330 96 57 B37.2: Monographella nivalis 0.0004 0 0.0005 0.0003 81 0.0004 0.0005 0.0003 95 81

TABLE B38 The abbreviations are defined as follows: 1.001 = compound No. 1.001 PTC = Prothioconazole FDL = Fludioxonil Solution of Solution of PTC + FDL expected 1.001 1:2 observed % action ppm ppm ppm activity (colby) B38.1: Alternaria solani 0.0008 4 0.0016 14 0.0031 46 0.0005 0.0010 0 0.0010 0.0021 0 0.0021 0.0042 6 0.0008 0.0005 0.0010 27 4 0.0008 0.0010 0.0021 25 4 0.0016 0.0021 0.0042 42 18 0.0031 0.0021 0.0042 75 49 B38.2: Fusarium culmorum 0.0125 9 0.0250 28 0.0500 52 0.0165 0.0335 9 0.0330 0.0670 12 0.0125 0.0165 0.0335 34 17 0.0250 0.0165 0.0335 44 35 0.0250 0.0330 0.0670 62 37 0.0500 0.0330 0.0670 64 57 B38.3: Botrytis cinerea 0.0016 21 0.0031 42 0.0063 64 0.0021 0.0042 4 0.0041 0.0084 1 0.0083 0.0168 25 0.0016 0.0021 0.0042 29 24 0.0031 0.0041 0.0084 69 43 0.0063 0.0041 0.0084 77 64 0.0063 0.0083 0.0168 96 73

TABLE B39 The abbreviations are defined as follows: 1.001 = compound No. 1.001 PTC = Prothioconazole CPL = Cyprodinil Solution of Solution of PTC + CPL expected 1.001 1:2 observed % action ppm ppm ppm activity (colby) B39.1: Monographella nivalis 0.0031 0 0.0063 0 0.0125 2 0.0041 0.0084 18 0.0083 0.0168 68 0.0031 0.0041 0.0084 45 18 0.0063 0.0041 0.0084 39 18 0.0063 0.0083 0.0168 86 68 0.0125 0.0083 0.0168 81 68 B39.2: Septoria tritici 0.0016 59 0.0001 0.0003 3 0.0016 0.0001 0.0003 78 60 B39.3: Botrytis cinerea 0.0031 39 0.0063 64 0.0003 0.0005 0 0.0010 0.0021 0 0.0021 0.0042 0 0.0041 0.0084 0 0.0031 0.0003 0.0005 54 39 0.0031 0.0010 0.0021 46 39 0.0031 0.0041 0.0084 68 39 0.0063 0.0021 0.0042 76 64 0.0063 0.0041 0.0084 73 64

TABLE B40 The abbreviations are defined as follows: 1.001 = compound No. 1.001 PTC = Prothioconazole FLN = Fluazinam Solution of Solution of PTC + FLN expected 1.001 1:3 observed % action ppm ppm ppm activity (colby) B40.1: Alternaria solani 0.0016 25 0.0031 50 0.0016 0.0047 5 0.0031 0.0094 5 0.0016 0.0016 0.0047 45 29 0.0031 0.0016 0.0047 62 53 0.0031 0.0031 0.0094 64 53 B40.2: Monographella nivalis 0.0031 2 0.0063 0 0.0125 2 0.0250 3 0.0500 0 0.0031 0.0094 13 0.0063 0.0188 38 0.0031 0.0031 0.0094 28 14 0.0063 0.0063 0.0188 98 38 0.0125 0.0063 0.0188 84 39 0.0250 0.0063 0.0188 61 40 0.0500 0.0063 0.0188 66 38 B40.3: Septoria tritici 0.0016 60 0.0031 89 0.0001 0.0003 0 0.0031 0.0094 0 0.0016 0.0001 0.0003 70 60 0.0031 0.0031 0.0094 99 89 B40.4: Botrytis cinerea 0.0016 26 0.0031 48 0.0063 66 0.0125 88 0.0016 0.0047 6 0.0031 0.0094 9 0.0063 0.0188 20 0.0016 0.0016 0.0047 60 30 0.0031 0.0016 0.0047 57 51 0.0031 0.0031 0.0094 96 52 0.0063 0.0031 0.0094 91 69 0.0063 0.0063 0.0188 100 73 0.0125 0.0063 0.0188 99 90

TABLE B41 The abbreviations are defined as follows: 1.001 = compound No. 1.001 TCZ = Tebuconazole PYS = Pyraclostrobin Solution of Solution of TCZ + PYS expected 1.001 2:1 observed % action ppm ppm ppm activity (colby) B41.1: Alternaria solani 0.0016 49 0.0031 81 0.0042 0.0021 5 0.0084 0.0041 17 0.0016 0.0042 0.0021 78 52 0.0031 0.0084 0.0041 94 84 B41.2: Monographella nivalis 0.0031 10 0.0063 14 0.0125 4 0.0250 23 0.0500 40 0.1000 67 0.0042 0.0021 23 0.0084 0.0041 10 0.0168 0.0083 32 0.0031 0.0042 0.0021 48 31 0.0031 0.0084 0.0041 64 19 0.0063 0.0084 0.0041 100 22 0.0063 0.0168 0.0083 90 42 0.0125 0.0168 0.0083 100 35 0.0250 0.0168 0.0083 66 48 0.0500 0.0084 0.0041 51 46 0.0500 0.0168 0.0083 77 59 0.1000 0.0168 0.0083 96 78 B41.3: Botrytis cinerea 0.0008 33 0.0016 54 0.0031 73 0.0063 88 0.0005 0.0003 3 0.0021 0.0010 0 0.0042 0.0021 0 0.0084 0.0041 7 0.0008 0.0021 0.0010 52 33 0.0016 0.0021 0.0010 78 54 0.0016 0.0042 0.0021 96 54 0.0031 0.0005 0.0003 81 74 0.0031 0.0021 0.0010 80 73 0.0031 0.0042 0.0021 98 73 0.0031 0.0084 0.0041 100 75 0.0063 0.0042 0.0021 97 88 0.0063 0.0084 0.0041 99 89

TABLE B42 The abbreviations are defined as follows: 1.001 = compound No. 1.001 TCZ = Tebuconazole TFS = Trifloxystrobin Solution of Solution of TCZ + TFS expected 1.001 2:1 observed % action ppm ppm ppm activity (colby) B42.1: Alternaria solani 0.0004 10 0.0008 30 0.0016 54 0.0010 0.0005 10 0.0021 0.0010 17 0.0042 0.0021 9 0.0004 0.0010 0.0005 30 19 0.0008 0.0021 0.0010 44 42 0.0016 0.0042 0.0021 74 58 B42.2: Fusarium culmorum 0.0125 16 0.0250 34 0.0500 54 0.1000 58 0.2000 59 0.0042 0.0021 1 0.0168 0.0083 1 0.0335 0.0165 2 0.0670 0.0330 6 0.1340 0.0660 6 0.1340 0.0660 8 0.0125 0.0168 0.0083 42 17 0.0125 0.0335 0.0165 58 18 0.0250 0.0042 0.0021 51 35 0.0250 0.0168 0.0083 51 35 0.0250 0.0335 0.0165 66 36 0.0250 0.0670 0.0330 71 39 0.0500 0.0168 0.0083 60 54 0.0500 0.0335 0.0165 69 55 0.0500 0.0670 0.0330 78 57 0.0500 0.1340 0.0660 75 57 0.1000 0.0335 0.0165 72 59 0.1000 0.0670 0.0330 78 61 0.1000 0.1340 0.0660 80 61 0.2000 0.0335 0.0165 75 60 0.2000 0.0670 0.0330 76 62 0.2000 0.1340 0.0660 83 63 B42.3: Rhizoctonia solani 0.0250 0 0.0500 0 0.1000 15 0.0670 0.0330 35 0.1340 0.0660 13 0.0250 0.0670 0.0330 51 35 0.0500 0.1340 0.0660 68 13 0.1000 0.1340 0.0660 52 26 B42.4: Septoria tritici 0.0004 9 0.0008 24 0.0016 64 0.0010 0.0005 10 0.0021 0.0010 34 0.0004 0.0010 0.0005 27 17 0.0008 0.0010 0.0005 65 32 0.0008 0.0021 0.0010 80 50 0.0016 0.0010 0.0005 88 67 0.0016 0.0021 0.0010 86 76 B42.5: Botrytis cinerea 0.0008 24 0.0016 45 0.0031 76 0.0021 0.0010 15 0.0042 0.0021 32 0.0008 0.0021 0.0010 72 35 0.0016 0.0021 0.0010 88 53 0.0016 0.0042 0.0021 98 62 0.0031 0.0021 0.0010 89 79 0.0031 0.0042 0.0021 99 83

TABLE B43 The abbreviations are defined as follows: 1.001 = compound No. 1.001 TCZ = Tebuconazole FDL = Fludioxonil Solution of Solution of TCZ + FDL expected 1.001 1:2 observed % action ppm ppm ppm activity (colby) B43.1: Alternaria solani 0.0016 45 0.0001 0.0003 0 0.0021 0.0042 0 0.0016 0.0001 0.0003 54 45 0.0016 0.0021 0.0042 78 45 B43.2: Fusarium culmorum 0.0250 34 0.0500 55 0.1000 55 0.2000 61 0.0330 0.0670 1 0.0660 0.1340 1 0.0660 0.1340 25 0.0250 0.0330 0.0670 56 34 0.0500 0.0330 0.0670 89 56 0.0500 0.0660 0.1340 100 67 0.1000 0.0330 0.0670 81 56 0.1000 0.0660 0.1340 97 66 0.2000 0.0330 0.0670 76 61 0.2000 0.0660 0.1340 98 71 B43.3: Monographella nivalis 0.0063 1 0.0125 4 0.0250 14 0.0500 11 0.0041 0.0084 24 0.0083 0.0168 70 0.0063 0.0083 0.0168 95 70 0.0125 0.0083 0.0168 98 71 0.0250 0.0041 0.0084 55 35 0.0250 0.0083 0.0168 100 74 0.0500 0.0041 0.0084 59 33 B43.4: Botrytis cinerea 0.0008 36 0.0016 51 0.0031 80 0.0005 0.0010 0 0.0010 0.0021 12 0.0021 0.0042 37 0.0041 0.0084 22 0.0008 0.0005 0.0010 42 36 0.0016 0.0021 0.0042 91 69 0.0031 0.0010 0.0021 94 82 0.0031 0.0041 0.0084 100 84

TABLE B44 The abbreviations are defined as follows: 1.001 = compound No. 1.001 TCZ = Tebuconazole CPL = Cyprodinil Solution of Solution of TCZ + CPL expected 1.001 1:2 observed % action ppm ppm ppm activity (colby) B44.1: Alternaria solani 0.0016 35 0.0001 0.0003 8 0.0003 0.0005 0 0.0005 0.0010 0 0.0010 0.0021 4 0.0021 0.0042 5 0.0016 0.0001 0.0003 57 40 0.0016 0.0003 0.0005 52 35 0.0016 0.0005 0.0010 47 35 0.0016 0.0010 0.0021 64 38 0.0016 0.0021 0.0042 52 39 B44.2: Monographella nivalis 0.0016 4 0.0031 0 0.0063 3 0.0021 0.0042 10 0.0041 0.0084 52 0.0016 0.0021 0.0042 35 14 0.0031 0.0041 0.0084 97 52 0.0063 0.0041 0.0084 91 53

TABLE B45 The abbreviations are defined as follows: 1.001 = compound No. 1.001 TCZ = Tebuconazole FLN = Fluazinam Solution of TCZ + FLN expected Solution of 1.001 1:3 observed % action ppm ppm ppm activity (colby) B45.1: Alternaria solani 0.0008 10 0.0016 40 0.0031 76 0.0001 0.0003 0 0.0002 0.0006 0 0.0004 0.0012 0 0.0008 0.0023 5 0.0016 0.0047 10 0.0031 0.0094 22 0.0008 0.0004 0.0012 27 10 0.0016 0.0001 0.0003 50 40 0.0016 0.0008 0.0023 46 43 0.0016 0.0016 0.0047 66 45 0.0031 0.0002 0.0006 88 76 0.0031 0.0016 0.0047 90 78 0.0031 0.0031 0.0094 92 81 B45.2: Monographella nivalis 0.0016 2 0.0031 0 0.0063 5 0.0125 5 0.0250 6 0.0500 9 0.0016 0.0047 0 0.0031 0.0094 45 0.0016 0.0016 0.0047 31 2 0.0031 0.0031 0.0094 90 45 0.0063 0.0031 0.0094 73 48 0.0125 0.0031 0.0094 79 48 0.0250 0.0016 0.0047 29 6 0.0500 0.0031 0.0094 84 50 B45.3: Botrytis cinerea 0.0008 36 0.0016 68 0.0031 86 0.0004 0.0012 3 0.0008 0.0023 8 0.0016 0.0047 6 0.0031 0.0094 10 0.0008 0.0004 0.0012 59 38 0.0008 0.0008 0.0023 85 41 0.0016 0.0008 0.0023 94 71 0.0016 0.0016 0.0047 99 70 0.0031 0.0016 0.0047 99 87 0.0031 0.0031 0.0094 100 88

TABLE B46 The abbreviations are defined as follows: 1.001 = compound No. 1.001 PYS = Pyraclostrobin TFS = Trifloxystrobin Solution of PYS + TFS expected Solution of 1.001 1:1 observed % action ppm ppm ppm activity (colby) B46.1: Alternaria solani 0.0016 53 0.0031 73 0.0002 0.0002 0 0.0008 0.0008 0 0.0031 0.0031 13 0.0063 0.0063 20 0.0016 0.0002 0.0002 65 53 0.0016 0.0031 0.0031 67 59 0.0031 0.0008 0.0008 80 73 0.0031 0.0031 0.0031 86 76 0.0031 0.0063 0.0063 89 78 B46.2: Monographella nivalis 0.0016 1 0.0031 2 0.0063 0 0.0250 7 0.0031 0.0031 25 0.0063 0.0063 66 0.0016 0.0031 0.0031 37 26 0.0031 0.0063 0.0063 98 67 0.0063 0.0031 0.0031 55 25 0.0063 0.0063 0.0063 76 66 0.0250 0.0063 0.0063 100 69 B46.3: Septoria tritici 0.0016 53 0.0004 0.0004 0 0.0016 0.0016 1 0.0031 0.0031 1 0.0016 0.0004 0.0004 61 53 0.0016 0.0016 0.0016 60 54 0.0016 0.0031 0.0031 66 54 B46.4: Botrytis cinerea 0.0016 43 0.0002 0.0002 3 0.0008 0.0008 0 0.0016 0.0002 0.0002 52 45 0.0016 0.0008 0.0008 51 43

TABLE B47 The abbreviations are defined as follows: 1.001 = compound No. 1.001 PYS = Pyraclostrobin FDL = Fludioxonil Solution of PYS + FDL expected Solution of 1.001 1:4 observed % action ppm ppm ppm activity (colby) B47.1: Alternaria solani 0.0016 53 0.0013 0.0050 2 0.0016 0.0013 0.0050 71 54 B47.2: Septoria tritici 0.0008 15 0.0016 53 0.0006 0.0025 14 0.0013 0.0050 39 0.0008 0.0006 0.0025 48 26 0.0016 0.0013 0.0050 90 71 B47.3: Botrytis cinerea 0.0016 42 0.0031 68 0.0013 0.0050 16 0.0025 0.0100 38 0.0016 0.0013 0.0050 88 51 0.0031 0.0013 0.0050 93 73 0.0031 0.0025 0.0100 99 80

TABLE B48 The abbreviations are defined as follows: 1.001 = compound No. 1.001 PYS = Pyraclostrobin CPL = Cyprodinil Solution of PYS + CPL expected Solution of 1.001 1:4 observed % action ppm ppm ppm activity (colby) B48.1: Alternaria solani 0.0008 24 0.0016 46 0.0001 0.0003 8 0.0003 0.0013 1 0.0006 0.0025 2 0.0013 0.0050 2 0.0008 0.0006 0.0025 34 26 0.0016 0.0001 0.0003 59 50 0.0016 0.0003 0.0013 55 47 0.0016 0.0006 0.0025 59 48 0.0016 0.0013 0.0050 70 48 B48.2: Fusarium culmorum 0.0125 10 0.0250 32 0.0500 59 0.1000 56 0.2000 60 0.0100 0.0400 12 0.0200 0.0800 8 0.0400 0.1600 8 0.0400 0.1600 35 0.0125 0.0100 0.0400 36 20 0.0250 0.0100 0.0400 46 40 0.0250 0.0200 0.0800 56 37 0.0500 0.0400 0.1600 100 73 0.1000 0.0200 0.0800 73 60 0.1000 0.0400 0.1600 98 71 0.2000 0.0400 0.1600 98 74 B48.3: Monographella nivalis 0.0250 15 0.0500 21 0.0050 0.0200 0 0.0200 0.0800 0 0.0400 0.1600 46 0.0250 0.0200 0.0800 48 15 0.0500 0.0050 0.0200 58 21 0.0500 0.0400 0.1600 85 57 B48.4: Rhizoctonia solani 0.0500 0 0.2000 0 0.0400 0.1600 16 0.0400 0.1600 61 0.0500 0.0400 0.1600 76 61 0.2000 0.0400 0.1600 72 61 B48.5: Septoria tritici 0.0016 58 0.0013 0.0050 0 0.0016 0.0013 0.0050 67 58 B48.6: Botrytis cinerea 0.0008 30 0.0016 59 0.0031 76 0.0002 0.0006 3 0.0006 0.0025 7 0.0013 0.0050 0 0.0025 0.0100 21 0.0008 0.0002 0.0006 44 32 0.0008 0.0006 0.0025 41 35 0.0016 0.0013 0.0050 91 59 0.0031 0.0006 0.0025 91 78 0.0031 0.0013 0.0050 85 76 0.0031 0.0025 0.0100 99 81

TABLE B49 The abbreviations are defined as follows: 1.001 = compound No. 1.001 PYS = Pyraclostrobin FLN = Fluazinam Solution of PYS + FLN expected Solution of 1.001 1:6 observed % action ppm ppm ppm activity (colby) B49.1: Monographella nivalis 0.0031 6 0.0018 0.0107 13 0.0031 0.0018 0.0107 86 18 B49.2: Botrytis cinerea 0.0016 48 0.0002 0.0013 0 0.0009 0.0054 0 0.0016 0.0002 0.0013 53 48 0.0016 0.0009 0.0054 56 48

TABLE B50 The abbreviations are defined as follows: 1.001 = compound No. 1.001 TFS = Trifloxystrobin FDL = Fludioxonil Solution of TFS + FDL expected Solution of 1.001 1:4 observed % action ppm ppm ppm activity (colby) B50.1: Fusarium culmorum 0.0125 11 0.0250 33 0.0500 56 0.1000 59 0.2000 65 0.0050 0.0200 2 0.0100 0.0400 20 0.0200 0.0800 29 0.0125 0.0050 0.0200 51 12 0.0125 0.0100 0.0400 50 28 0.0250 0.0050 0.0200 50 34 0.0250 0.0100 0.0400 62 46 0.0250 0.0200 0.0800 100 53 0.0500 0.0200 0.0800 93 69 0.1000 0.0200 0.0800 88 71 0.2000 0.0200 0.0800 93 76 B50.2: Monographella nivalis 0.0004 0 0.0008 3 0.0003 0.0013 44 0.0004 0.0003 0.0013 67 44 0.0008 0.0003 0.0013 73 46 B50.3: Rhizoctonia solani 0.1000 0 0.2000 0 0.0400 0.1600 30 0.0400 0.1600 65 0.1000 0.0400 0.1600 99 65 0.2000 0.0400 0.1600 96 65 B50.4: Septoria tritici 0.0008 27 0.0016 56 0.0006 0.0025 10 0.0013 0.0050 21 0.0008 0.0006 0.0025 47 34 0.0016 0.0006 0.0025 78 60 0.0016 0.0013 0.0050 73 65 B50.5: Botrytis cinerea 0.0008 9 0.0016 26 0.0031 49 0.0006 0.0025 6 0.0013 0.0050 33 0.0025 0.0100 37 0.0008 0.0006 0.0025 22 14 0.0016 0.0013 0.0050 78 50 0.0031 0.0025 0.0100 89 68

TABLE B51 The abbreviations are defined as follows: 1.001 = compound No. 1.001 TFS = Trifloxystrobin CPL = Cyprodinil Solution of TFS + CPL expected Solution of 1.001 1:4 observed % action ppm ppm ppm activity (colby) B51.1: Fusarium culmorum 0.0250 29 0.0500 54 0.1000 57 0.2000 58 0.0100 0.0400 7 0.0200 0.0800 6 0.0400 0.1600 6 0.0400 0.1600 8 0.0250 0.0100 0.0400 56 34 0.0250 0.0200 0.0800 70 33 0.0500 0.0100 0.0400 64 57 0.0500 0.0200 0.0800 77 56 0.0500 0.0400 0.1600 80 58 0.1000 0.0100 0.0400 67 60 0.1000 0.0200 0.0800 77 60 0.1000 0.0400 0.1600 84 61 0.2000 0.0200 0.0800 73 60 0.2000 0.0400 0.1600 83 62 B51.2: Monographella nivalis 0.0004 2 0.0008 0 0.0016 0 0.0031 2 0.0125 0 0.0003 0.0013 46 0.0006 0.0025 88 0.0004 0.0003 0.0013 98 48 0.0008 0.0003 0.0013 93 46 0.0008 0.0006 0.0025 98 88 0.0016 0.0006 0.0025 98 88 0.0031 0.0006 0.0025 97 88 0.0125 0.0006 0.0025 97 88 B51.3: Septoria tritici 0.0008 18 0.0016 47 0.0006 0.0025 10 0.0013 0.0050 25 0.0008 0.0006 0.0025 34 26 0.0016 0.0013 0.0050 78 60

TABLE B52 The abbreviations are defined as follows: 1.001 = compound No. 1.001 TFS = Trifloxystrobin FLN = Fluazinam Solution of TFS + FLN expected Solution of 1.001 1:6 observed % action ppm ppm ppm activity (colby) B52.1: Alternaria solani 0.0016 21 0.0031 57 0.0009 0.0054 5 0.0016 0.0009 0.0054 48 25 0.0031 0.0009 0.0054 82 59 B52.2: Fusarium culmorum 0.0125 6 0.0250 26 0.0072 0.0428 23 0.0143 0.0857 30 0.0125 0.0072 0.0428 40 28 0.0250 0.0143 0.0857 58 48 B52.3: Monographella nivalis 0.0004 3 0.0063 2 0.0002 0.0013 38 0.0004 0.0002 0.0013 97 40 0.0063 0.0002 0.0013 85 39 B52.4: Botrytis cinerea 0.0016 29 0.0031 58 0.0063 74 0.0009 0.0054 18 0.0018 0.0107 76 0.0016 0.0009 0.0054 84 42 0.0031 0.0009 0.0054 91 65 0.0031 0.0018 0.0107 100 90 0.0063 0.0009 0.0054 88 79

TABLE B53 The abbreviations are defined as follows: 1.001 = compound No. 1.001 FDL = Fludioxonil CPL = Cyprodinil Solution of FDL + CPL expected Solution of 1.001 (1:1) observed % action ppm ppm ppm activity (colby) B53.1: Fusarium culmorum 0.0500 49 0.1000 59 0.2000 55 0.1000 0.1000 8 0.1000 0.1000 6 0.0500 0.1000 0.1000 81 51 0.1000 0.1000 0.1000 85 62 0.2000 0.1000 0.1000 84 58 B53.2: Monographella nivalis 0.0063 0 0.0125 0 0.0125 0.0125 26 0.0063 0.0125 0.0125 67 26 0.0125 0.0125 0.0125 46 26 B53.3: Botrytis cinerea 0.0016 49 0.0031 71 0.0063 87 0.0031 0.0031 3 0.0063 0.0063 4 0.0125 0.0125 16 0.0016 0.0031 0.0031 61 50 0.0031 0.0063 0.0063 91 72 0.0063 0.0063 0.0063 97 87 0.0063 0.0125 0.0125 100 89

TABLE B54 The abbreviations are defined as follows: 1.001 = compound No. 1.001 FDL = Fludioxonil FLN = Fluazinam Solution of FDL + FLN expected Solution of 1.001 (2:3) observed % action ppm ppm ppm activity (colby) B54.1: Alternaria solani 0.0008 42 0.0002 0.0002 3 0.0008 0.0002 0.0002 65 44 B54.2: Fusarium culmorum 0.0500 51 0.1000 55 0.2000 60 0.0400 0.0600 0 0.0800 0.1200 0 0.0800 0.1200 15 0.0500 0.0400 0.0600 64 51 0.0500 0.0800 0.1200 87 59 0.1000 0.0400 0.0600 61 55 0.1000 0.0800 0.1200 87 62 0.2000 0.0400 0.0600 75 60 0.2000 0.0800 0.1200 88 66 B54.3: Monographella nivalis 0.0500 3 0.1000 22 0.0100 0.0150 5 0.0200 0.0300 0 0.0400 0.0600 1 0.0800 0.1200 67 0.0500 0.0400 0.0600 38 4 0.0500 0.0800 0.1200 100 68 0.1000 0.0100 0.0150 39 26 0.1000 0.0200 0.0300 46 22 0.1000 0.0400 0.0600 68 23 0.1000 0.0800 0.1200 94 74 B54.4: Botrytis cinerea 0.0008 34 0.0031 75 0.0063 89 0.0002 0.0002 9 0.0050 0.0075 4 0.0100 0.0150 8 0.0008 0.0002 0.0002 61 40 0.0031 0.0050 0.0075 89 76 0.0063 0.0050 0.0075 98 90 0.0063 0.0100 0.0150 100 90

TABLE B55 The abbreviations are defined as follows: 1.001 = compound No. 1.001 CPL = Cyprodinil FLN = Fluazinam Solution of CPL + FLN expected Solution of 1.001 (2:3) observed % action ppm ppm ppm activity (colby) B55.1: Alternaria solani 0.0016 55 0.0002 0.0002 0 0.0003 0.0005 9 0.0016 0.0002 0.0002 69 55 0.0016 0.0003 0.0005 69 59 B55.2: Fusarium culmorum 0.0250 0.2000 51 0.0025 0.0038 0 0.0200 0.0300 0 0.0250 0.0025 0.0038 44 16 0.2000 0.0200 0.0300 60 51 B55.3: Monographella nivalis 0.1000 19 0.2000 79 0.0100 0.0150 2 0.0200 0.0300 28 0.1000 0.0100 0.0150 41 21 0.2000 0.0200 0.0300 90 85 B55.4: Septoria tritici 0.0016 63 0.0002 0.0002 5 0.0016 0.0002 0.0002 82 65 B55.5: Botrytis cinerea 0.0016 38 0.0031 53 0.0063 66 0.0125 83 0.0013 0.0019 1 0.0050 0.0075 4 0.0100 0.0150 4 0.0016 0.0013 0.0019 58 38 0.0031 0.0050 0.0075 76 55 0.0063 0.0050 0.0075 94 67 0.0063 0.0100 0.0150 100 67 0.0125 0.0013 0.0019 94 84 0.0125 0.0050 0.0075 97 84 0.0125 0.0100 0.0150 100 84 

What is claimed:
 1. A composition suitable for control of diseases caused by phytopathogens comprising: (A) 3-(difluoromethyl)-N-methoxy-1-methyl-N-[1-methyl-2-(2,4,6-trichlorophenyl)ethyl]pyrazole-4-carboxamide; (B) difenoconazole; and (C) azoxystrobin; wherein the weight ratio of (A) to (B+C) is from 4:1 to 1:4.
 2. The composition according to claim 1, wherein the weight ratio of component (B) to component (C) is from 2:1 to 1:6.
 3. A method of controlling diseases on useful plants or on propagation material thereof caused by phytopathogens, which comprises applying to the useful plants, the locus thereof or propagation material thereof a composition according to claim
 1. 4. A method of protecting natural substances of plant and/or animal origin, which have been taken from the natural life cycle, and/or their processed forms, which comprises applying to said natural substances of plant and/or animal origin or their processed forms a combination of components (A), (B) and (C) according to claim
 1. 